盐酸左氧氟沙星滴耳液治疗急性化脓性中耳炎的临床价值分析

Clinical value of levofloxacin hydrochloride ear drops in the treatment of acute suppurative otitis media

目的探究盐酸左氧氟沙星滴耳液治疗急性化脓性中耳炎的临床价值。方法选取本院2014年1月至2019年1月耳鼻喉科收治的急性化脓性中耳炎患者138例,按随机数表法分成对照组与观察组,各69例。对照组采用氯霉素滴耳液治疗,观察组采用盐酸左氧氟沙星滴耳液治疗,连续治疗10 d后,观察对比两组临床疗效、致病菌清除率和血清炎性指标。结果治疗后,观察组临床总有效率、致病菌清除率高于对照组,比较差异有统计学意义(P<0.05);治疗后,两组炎性因子TNF-α、IL-1β、IL-8均明显下降,且观察组低于对照组,差异有统计学意义(P<0.05)。结论相比氯霉素滴耳液,盐酸左氧氟沙星滴耳液提高急性化脓性中耳炎的临床疗效更佳,可增加致病菌清除率,降低炎性因子水平,值得临床推广。

Objective To explore the clinical value of levofloxacin hydrochloride ear drops in the treatment of acute suppurative otitis media.Methods 138 patients with acute suppurative otitis media were selected from the Department of Otorhinolaryngology in our hospital from January 2014 to January 2019.They were randomly divided into control group and observation group,with 69 cases in each group.The control group was treated with chloramphenicol ear drops,while the observation group was treated with levofloxacin hydrochloride ear drops.After 10 days of continuous treatment,the clinical efficacy,pathogenic bacteria clearance rate and serum inflammatory index of the two groups were observed and compared between two groups.Results After treatment,compared with the control group,the total clinical effective rate and the clearance rate of pathogenic bacteria in the observation group were higher,the difference was statistically significant(P<0.05).After treatment,the inflammatory factors of TNF-α,IL-1βand IL-8 in the two groups were significantly decreased,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).Conclusion Compared with chloramphenicol ear drops,the clinical efficacy of levofloxacin hydrochloride ear drops is higher,and can increase the clearance rate of pathogenic bacteria and reduce the level of inflammatory factors.