某院82例肝硬化合并自发性细菌性腹膜炎的危险因素分析

Correlation analysis of risk factors in 82 cases of cirrhosis with spontaneous bacterial peritonitis

目的探讨肝硬化患者合并自发性细菌性腹膜炎(SBP)的相关危险因素,为临床防控提供理论依据。方法以2016年1月~2019年10月某院收治的肝硬化合并自发性细菌性腹膜炎患者82例为观察组。选取同期在某院治疗的肝硬化未合并自发性细菌性腹膜炎的患者74例为对照组。回顾性分析观察组和对照组患者临床资料,并汇总统计分析两组患者性别、年龄、糖尿病史、SBP史、是否合并消化道出血、腹水白细胞计数、腹水白蛋白水平以及肝功能分级等资料,并进行相关性分析。结果观察组和对照组患者在合并糖尿病、合并消化道出血、SBP史、腹水白蛋白、肝功能分级、合并肝性脑病方面比较差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,合并糖尿病、合并消化道出血、SBP史、腹水白蛋白<10 g/L是肝硬化患者合并SBP的独立危险因素(OR>1,P<0.05)。结论肝硬化患者合并SBP因素较多,临床应当对于合并糖尿病、消化道出血、有SBP史以及腹水白蛋白较低的患者高度重视,进行早期预防干预。

Objective To explore correlation analysis of patients of cirrhosis with spontaneous bacterial peritonitis.Methods From January 2016 to October 2019,82 patients of cirrhosis with spontaneous bacterial peritonitis were taken as the observation group,and 74 cases of cirrhosis without spontaneous bacterial peritonitis were selected as the control group.The data of sex,age,history of diabetes,SBP history,gastrointestinal hemorrhage,leukocyte count of ascites,albumin level of ascites and liver function grade were analyzed retrospectively.Results There were significant differences between the two groups in terms of diabetes mellitus,gastrointestinal hemorrhage,SBP history,ascites albumin,liver function grade,and hepatic encephalopathy(P<0.05).Multivariate logistic regression analysis showed that the risk factors of cirrhosis with SBP were diabetes mellitus,gastrointestinal hemorrhage,SBP history and ascites albumin<10 g/L(OR>1,P<0.05).Conclusion There are many factors of cirrhosis with SBP in patients,so we should pay more attention to the patients with diabetes,gastrointestinal bleeding,SBP history and low ascites albumin,and carry out early prevention and intervention.