放射性心脏损伤动物模型相关实验研究进展

Advances in experimental research on radiation-induced heart injury in animal models

当利用放射线对胸部恶性肿瘤进行治疗时,位于纵隔的心脏会不可幸免受到照射,从而诱发放射性心脏损伤(radiation-induced heart disease, RIHD)。随着手术以及放化疗技术的提升,肿瘤患者生存时间得到延长,使得RIHD这一放疗远期并发症被越来越多的报道。因此,学者们对于RIHD的研究逐渐升温。目前国内外学者关于该疾病尚未形成统一的认识,临床上缺乏有效阻止其发生的方法。动物模型研究可为临床该疾病治疗及预防提供可靠证据,为此本文回顾分析近年来放射性心脏损伤动物模型实验研究情况,旨在为后续实验开展及临床应用提供参考。

When radiation was used for the treatment of chest malignant tumor,the heart will be irradiated inevitably,which led to radiation-induced heart disease(RIHD).With the improvement of radiotherapy and chemotherapy,the survival time of cancer patients had been extended Therefore,the research on RIHD had been attracted more and more attention.At present,scholars have not formed a unified understanding of this diseaseand there is no effective method to prevent its occurrence in clinical practice at home and abroad.Animal model research can provide reliable evidence for clinical treatment and prevention of this disease.For this reason,this paper reviews and analyzes the animal model research of radioactive heart injury in recent years,which aiming to provide reference for the development of follow-up experiments and clinical application.