妊娠期肝内胆汁淤积症与胎儿心脏损害

Intrahepatic cholestasis of pregnancy and fetal cardiac damage

严重妊娠期肝内胆汁淤积症时胎儿宫内死亡率明显增加,目前认为心脏因素可能是引起胎儿宫内死亡的重要原因。而妊娠期肝内胆汁淤积症引起胎儿心脏损害的机制目前尚不十分清楚,其焦点仍然集中在胎盘的急性缺氧学说和胆汁酸的毒性作用。本文对妊娠期肝内胆汁淤积症导致胎儿心脏损害的相关研究进展进行综述。

The risk of intrauterine death increases significantly in women with severe intrahepatic cholestasis of pregnancy.Fetal cardiac factors are considered to be possible important causes.However,the mechanisms of intrahepatic cholestasis of pregnancy causing fetal cardiac damage are still unclear.The possible mechanisms focus on the theories of acute hypoxia of the placenta and the toxic effects of bile acids.In this paper we summarize the studies on fetal heart damage caused by intrahepatic cholestasis of pregnancy,with a view to raising awareness of this disease.