青年型肺癌的临床和基因表型特征研究现状

Current Situation of Clinical Feature and Gene Phenotype of Young Adult Lung Cancer

青年型肺癌的义为发病年龄≤40岁且≥18岁的的肺癌患者。与传统肺癌相比,青年型肺癌患者起病隐匿,临床症状不典型,在发现时分期通常较晚,多数出现区域淋巴转移或远处转移。目前研究发现,青年型肺癌具有相对独特的基因背景,其肿瘤驱动基因丰度较高,且与其临床表现和预后有着较为密切的关系。青年型肺癌是近年来肿瘤领域关注的热点,本文就青年型肺癌的临床特征,基因表型特点及预后复习文献并综述,旨在为青年型肺癌的诊疗及临床研究提供一些参考与线索。

Young adult lung cancer is defined as a group of patients refers to whose onset age is less than 40 years old and ≥18 years old. Compare with elder lung cancer, the clinical symptoms of them are not typical, the stage is usually late at the time of discovery, and most of them have regional lymphatic metastasis or distant metastasis. Current study found that young adult lung cancer has a relatively unique genetic background, the abundance of tumor-driving genes is high, and it is closely related to its clinical manifestation and prognosis. Young adult lung cancer is the focus of attention in the field of cancer in recent years. This article reviewed the literature on the clinical features, gene phenotypic characteristics and prognosis of young adult lung cancer in order to provide provide some references and clues for the study on young adult lung cancer.