成纤维细胞生长因子5的研究进展

Research Progress of Fibroblast Growth Factor 5

成纤维细胞生长因子5(fibroblast growth factor 5,FGF5)是成纤维细胞生长因子家族(FGFs)的成员之一,在哺乳动物毛囊、神经系统、睾丸等多个部位及胚胎发育过程中均有表达。研究发现,FGF5具有广泛的生物学活性,如作为毛发生长重要的调节因子其编码基因突变将导致毛发异常生长,作为丝裂原在干细胞增殖、血管生成和肢体肌发育等方面发挥重要作用,以及在高血压、肿瘤等方面具有重要的生物学功能。目前,FGF5在多种疾病中的功能和作用机制尚需进一步深入研究,但其在毛发生长、干细胞增殖及在心血管疾病等方面的生物学作用具有重大的意义和临床应用价值。总结了近些年FGF5的研究进展,系统阐述了FGF5在毛发生长、干细胞增殖分化、心血管疾病及癌症等方面的相关作用机制,为进一步深入研究FGF5在疾病治疗中的作用和开发利用提供参考。

Fibroblast growth factor 5(FGF5)is a member of the fibroblast growth factor family(FGFs)and is expressed in mammalian hair follicles,nervous system,testis and other parts of the embryo and during embryonic development.The study found that FGF5 has a wide range of biological activities,such as an important regulator of hair growth,its genetic mutation will lead to abnormal hair growth;as a mitogen plays an important role in stem cell proliferation,angiogenesis and limb muscle development;It has important biological functions in hypertension and tumors.At present,the function and mechanism of action of FGF5 in various diseases need further study,but its biological effects in hair growth,stem cell proliferation and cardiovascular diseases have great significance and clinical application value.The research progress of FGF5 in recent years,systematically expounds the related mechanism of FGF5 in hair growth,stem cell proliferation and differentiation,cardiovascular disease and cancer,and provides further research on the role and development of FGF5 in disease treatment were summarized.