血清hs-CRP、Cys C、UA水平与H型高血压合并脑梗死患者动脉粥样硬化程度的关系研究

Study on the relationship between the levels of serum hs-CRP,Cys C,UA and the degree of atherosclerosis in patients with H-type hypertension and cerebral infarction

目的研究血清超敏C反应蛋白(hs-CRP)、胱抑素C(Cys C)及尿酸(UA)水平与H型高血压合并脑梗死患者动脉粥样硬化程度的关系。方法选取2016年7月至2019年1月攀枝花市中西医结合医院收治的H型高血压合并脑梗死患者83例为观察组,观察组患者按照颈动脉内膜中层厚度(IMT)又分为IMT正常组(25例)、IMT增厚组(27例)及斑块组(31例),另选择同期体检健康者80例为对照组。采用酶联免疫吸附试验检测血清hs-CRP、Cys C及UA水平。比较各组血清hs-CRP、Cys C及UA水平;采用Spearman相关分析研究观察组血清hs-CRP、Cys C、UA水平及年龄与IMT的相关性;采用多因素Logistic回归分析观察组IMT增厚的独立危险因素。结果观察组血清hs-CRP、Cys C及UA水平均高于对照组(P<0.05)。斑块组血清hs-CRP、Cys C及UA水平均高于IMT正常组及IMT增厚组(P<0.05);IMT增厚组血清hs-CRP、Cys C水平均高于IMT正常组(P<0.05)。IMT与血清hs-CRP、Cys C、UA水平及年龄均呈正相关(r=0.643、0.726、0.744、0.502,P<0.05)。血清hs-CRP、Cys C、UA是导致观察组IMT增厚的独立危险因素(P<0.05)。结论H型高血压合并脑梗死患者血清hs-CRP、Cys C及UA水平升高,hs-CRP、Cys C及UA是导致其动脉粥样硬化病情进展的独立危险因素。

Objective To study the relationship between the levels of serum hypersensitive C-reactive protein(hs-CRP),cystatin C(Cys C),uric acid(UA)and the degree of atherosclerosis in patients with H-type hypertension and cerebral infarction.Methods From July 2016 to January 2019,83 patients with H-type hypertension and cerebral infarction treated in Panzhihua Traditional Chinese and Western Medicine Hospital were selected as the observation group,according to the carotid intima-media thickness(IMT),the patients in the observation group were divided into normal IMT group(25 cases),thickened IMT group(27 cases)and plaque group(31 cases),another 80 healthy people underwent physical examination in the same period were selected as the control group.The levels of serum hs-CRP,Cys C and UA were detected by ELISA.Serum hs-CRP,Cys C and UA levels were compared in each group;Spearman correlation analysis was used to study the correlation of serum hs-CRP,Cys C,UA levels,age and IMT;the independent risk factors of IMT thickening in the observation group were analyzed by multivariate Logistic regression.Results The levels of hs-CRP,Cys C and UA in observation group were higher than those in control group(P<0.05).The levels of hs-CRP,Cys C and UA in plaque group were higher than those in normal IMT group and thickened IMT group(P<0.05);the levels of hs-CRP and Cys C in thickened IMT group were higher than those in normal IMT group(P<0.05).IMT was positively correlated with hs-CRP,Cys C,UA levels and age(r=0.643,0.726,0.744,0.502,P<0.05).Serum hs-CRP,Cys C and UA were independent risk factors for IMT thickening in observation group(P<0.05).Conclusion Serum levels of hs-CRP,Cys C and UA are increased in patients with H-type hypertension and cerebral infarction,hs-CRP,Cys C and UA are independent risk factors for the progression of atherosclerosis.