急性缺血性脑卒中患者RDW、UA水平变化及应用价值研究

Study on the changes and application value of RDW and UA in patients with acute ischemic stroke

目的探讨急性缺血性脑卒中(AIS)患者红细胞分布宽度(RDW)、尿酸(UA)的水平变化及临床应用价值。方法选取2018年7月至2019年10月就诊于该院的AIS患者138例作为病例组,另选取同期假性卒中患者149例作为对照组。收集所有研究对象的一般资料和入院当日实验室指标的基线数据。比较病例组与对照组的RDW、UA水平;比较AIS不同病因学分型患者的RDW、UA水平;采用多因素Logistic回归分析AIS发生的独立危险因素。结果病例组RDW、UA水平均高于对照组,差异有统计学意义(P<0.05)。AIS不同病因学分型患者RDW、UA水平比较,差异均无统计学意义(P>0.05)。多因素Logistic回归分析结果显示,RDW、UA、年龄、吸烟史、高脂血症是AIS发生的独立危险因素(P<0.05)。结论RDW和UA水平在AIS患者中明显升高,是AIS发生的独立危险因素。

Objective To explore the changes of the red blood cell distribution width(RDW)and uric acid(UA)in patients with acute ischemic stroke(AIS)and its clinical application value.Methods A total of 138 AIS patients treated in the hospital from July 2018 to October 2019 were selected as the case group,and 149 patients with stroke mimics in the same period were selected as the control group.General information of all research subjects and baseline data of laboratory indicators on the day of admission were collected.The levels of RDW and UA in the case group and the control group were compared;the levels of RDW and UA in AIS patients with different etiological classifications were compared;multivariate Logistic regression was used to analyze the independent risk factors for the occurrence of AIS.Results The levels of RDW and UA in the case group were higher than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in the levels of RDW and UA among patients with different etiological classifications of AIS(P>0.05).Multivariate Logistic regression analysis results showed that RDW,UA,age,smoking history and hyperlipidemia were independent risk factors for the occurrence of AIS(P<0.05).Conclusion The levels of RDW and UA in AIS patients are significantly increased,which are independent risk factors for the occurrence of AIS.