血清LncRNA MIAT、MMP-2、MMP-9在胃癌诊断及预后评估中的价值

Value of serum LncRNA MIAT,MMP-2 and MMP-9 in diagnosis and prognosis evaluation of gastric cancer

目的探讨血清长链非编码RNA心肌梗死转录本(LncRNA MIAT)、基质金属蛋白酶(MMP)-2和MMP-9在胃癌诊断及预后评估中的价值。方法选取2014年4月至2016年9月于随州市中医医院确诊的胃癌患者120例为胃癌组,130例胃良性疾病患者为良性病变组,同期体检健康者120例为对照组。比较各组LncRNA MIAT、MMP-2与MMP-9水平;分析LncRNA MIAT、MMP-2、MMP-9水平与胃癌病理特征的关系;分析LncRNA、MMP-2、MMP-9对胃癌的诊断价值、预测价值及对预后的影响。结果胃癌组血清LncRNA MIAT、MMP-2与MMP-9水平均高于良性病变组与对照组(P<0.05)。血清LncRNA MIAT、MMP-2、MMP-9水平与肿瘤部位无明显关系(P>0.05),与胃癌的TNM分期及组织学类型有关(P<0.05)。受试者工作特征曲线分析结果显示,LncRNA MIAT、MMP-2和MMP-9联合检测诊断胃癌的曲线下面积为0.937,灵敏度为79.9%,特异度为94.3%。危险因素分析结果显示,血清LncRNA MIAT、MMP-2和MMP-9是胃癌发生的独立危险因素(P<0.05)。生存曲线分析结果显示,相比低水平LncRNA MIAT患者,高水平LncRNA MIAT患者中位生存时间明显缩短(P<0.05);相比低水平MMP-2患者,高水平MMP-2患者中位生存时间明显缩短(P<0.05);相比低水平MMP-9患者,高水平MMP-9患者中位生存时间明显缩短(P<0.05)。结论血清LncRNA MIAT、MMP-2和MMP-9在胃癌的诊断及预后评估中具有一定价值。

Objective To explore the value of serum long non-coding RNA myocardial infarction associated transcript(LncRNA MIAT),matrix metalloproteinase(MMP)-2 and MMP-9 in the diagnosis and prognosis evaluation of gastric cancer.Methods A total of 120 gastric cancer patients diagnosed in Suizhou Traditional Chinese Medicine Hospital from April 2014 to September 2016 were selected as the gastric cancer group,130 patients with benign gastric diseases were selected as the benign lesion group,and 120 healthy person underwent physical examination in the same period were selected as the control group.The levels of LncRNA MIAT,MMP-2 and MMP-9 of each group were compared;the relationship between the levels of LncRNA MIAT,MMP-2,MMP-9 and the pathological characteristics of gastric cancer were analyzed;the diagnostic value,predictive value and the impact on the prognosis of LncRNA MIAT,MMP-2,MMP-9 in gastric cancer were analyzed.Results The levels of serum LncRNA MIAT,MMP-2 and MMP-9 in gastric cancer group were higher than those in benign lesion group and control group(P<0.05).Serum LncRNA MIAT,MMP-2,MMP-9 levels had no significant relationship with the tumor site(P>0.05),and were related to the TNM stage and histological type of gastric cancer(P<0.05).The receiver operating characteristic curve analysis results showed that the area under the curve of the combined detection of LncRNA MIAT,MMP-2 and MMP-9 in the diagnosis of gastric cancer was 0.937,the sensitivity was 79.9%,and the specificity was 94.3%.Risk factor analysis results showed that serum LncRNA MIAT,MMP-2 and MMP-9 were independent risk factors for gastric cancer(P<0.05).Survival curve analysis results showed that compared with patients with low LncRNA MIAT levels,the median survival time of patients with high LncRNA MIAT levels was significantly shortened(P<0.05);compared with patients with low MMP-2 levels,the median survival time of patients with high MMP-2 levels was significantly shortened(P<0.05);compared with patients with low MMP-9 levels,the median survival time of patients with high MMP-9 levels was significantly shortened(P<0.05).Conclusion Serum LncRNA MIAT,MMP-2 and MMP-9 have certain value in the diagnosis and prognostic evaluation of gastric cancer.