锌指E盒结合蛋白1在子宫内膜癌患者中的表达及意义

Expression and significance of zinc finger E-box binding protein 1 in patients with endometrial cancer

目的探讨锌指E盒结合蛋白1(ZEB1)在子宫内膜癌患者中的表达及意义。方法选取该院2015年1月至2018年6月收治的子宫内膜癌患者150例为观察组,另选取同期150例健康体检者为对照组。根据子宫内膜癌高、中、低分化标准对观察组进行病理分级,其中高分化(G1组)57例,中分化(G2组)78例,低分化(G3组)15例。采用免疫组织化学法检测所有研究对象的ZEB1表达情况。比较观察组与对照组的ZEB1表达情况;比较不同病理分级患者的ZEB1表达情况;分析观察组ZEB1表达情况与子宫内膜癌临床病理特征的关系。结果观察组ZEB1阳性率为66.67%,明显高于对照组的13.33%(P<0.05)。G1、G2、G3组ZEB1阳性率均高于对照组(P<0.05);G3组ZEB1阳性率高于G2、G1组(P<0.05);G2组ZEB1阳性率高于G1组(P<0.05)。观察组肿瘤分期越高、肌层浸润深度越深、存在淋巴结转移患者的ZEB1阳性率越高(P<0.05)。结论ZEB1在子宫内膜癌组织中呈高表达,且子宫内膜癌病理分级越高,ZEB1阳性率越高;不同肿瘤分期、浸润深度及有无淋巴结转移患者的ZEB1表达具有明显差异,ZEB1可能参与了子宫内膜癌的发生、发展过程。

Objective To investigate the expression and significance of zinc finger E-box binding protein 1(ZEB1)in patients with endometrial cancer.Methods From January 2015 to June 2018,150 patients with endometrial cancer treated in the hospital were selected as the observation group,and 150 healthy people underwent physical examination in the same period were selected as the control group.The pathological grades of observation group were classified according to the criteria of high,medium and low differentiation of endometrial cancer,including 57 cases with high differentiation(G1 group),78 cases with medium differentiation(G2 group)and 15 cases with low differentiation(G3 group).The expression of ZEB1 in all subjects was detected by immunohistochemistry.The expression of ZEB1 was compared between the observation group and the control group;the expression of ZEB1 in patients with different pathological grades were compared;the relationship between the expression of ZEB1 and the clinicopathological characteristics of endometrial cancer in the observation group was analyzed.Results The positive rate of ZEB1 in the observation group was 66.67%,which was significantly higher than that in the control group(13.33%)(P<0.05).The positive rate of ZEB1 in the G1,G2 and G3 group was higher than that in the control group(P<0.05);the positive rate of ZEB1 in the G3 group was higher than that in the G2 and G1 group(P<0.05);the positive rate of ZEB1 in the G2 group was higher than that in the G1 group(P<0.05).The positive rates of ZEB1 were higher in the observation group of higher tumor stages,deeper myometrial infiltration and with lymph node metastasis(P<0.05).Conclusion ZEB1 is highly expressed in endometrial cancer tissue,and the higher the pathological grades of endometrial cancer,the higher the positive rate of ZEB1.There are significant differences in ZEB1 expression in patients with different tumor stages,depth of myometrial infiltration and with or without lymph node metastasis.ZEB1 may be involved in the occurrence and development of endometrial cancer.