人工髋关节摩擦界面蛋白质吸附变性分解行为及类石墨碳润滑层形成的分子机制

Adsorption,Denaturation and Decomposition of Proteins in Friction Interface for Artificial Hip Joint and Molecular Mechanism of Formation of Graphite-like Carbon Lubrication Layer

人工关节置换术被认为是治疗晚期关节炎、关节功能丧失等关节类疾病最有效和最终的治疗方式。首先介绍了人工髋关节体内服役环境特点及关节摩擦界面生物蛋白膜与类石墨碳润滑层的形成,进一步论述了在模拟体内服役环境下,过渡族金属铜催化摩擦界面的蛋白质变性降解,促进生物蛋白膜向类石墨碳润滑层的转变,最后探讨了过渡族金属离子介导产生活性氧自由基(ROS)催化蛋白质吸附、变性、分解及生物蛋白膜、类石墨碳润滑层形成的分子机制,并对未来陶瓷人工关节材料的设计提出展望。

Artificial joint replacement is considered to be the most effective and ultimate treatment for joint diseases such as advanced arthritis and joint dysfunction.The in vivo service environment characteristics of artificial hip joint,and the formation of biofilm and graphite-like carbon lubrication layer in friction interface were introduced firstly.The denaturation and degradation of proteins at the friction interface catalyzed by transition metal copper under the simulated in vivo service environment were further discussed and the transformation from biofilm to graphite-like carbon lubrication layer was also investigated.The molecular mechanism of transition metal ions producing reactive oxygen species,catalyzing the adsorption,denaturation and decomposition of proteins and forming biofilm,graphite-like carbon lubrication layer was studied,and the design of ceramic artificial joint material was prospected.