高压氧治疗对乳腺癌放化疗患者术后并发症及免疫功能的影响

Effects of hyperbaric oxygen therapy on immune function and quality of life of patients with breast cancer undergoing radiochemotherapy

目的探讨高压氧(HBO)治疗对乳腺癌放化疗患者术后并发症及免疫功能的影响。方法选取2015年2月至2018年2月福建省立金山医院普外科收治的100例乳腺癌术后放化疗患者,按照随机数字表法分为观察组和对照组,每组50例。对照组患者进行常规放化疗及临床对症治疗,观察组在对照组患者治疗的基础上加用HBO治疗。治疗后1周评估并记录患者皮瓣缺血坏死、皮下积液、切口感染、患肢水肿的发生情况;治疗5个疗程后,比较2组患者治疗前后WBC、PLT计数及血红蛋白(Hb)含量的变化,并检测血清免疫功能指标CD4^+、CD8^+及CD4^+/CD8^+的水平。结果治疗5个疗程后,观察组患者皮瓣缺血坏死、皮下积液、切口感染发生率明显低于对照组,差异有统计学意义(χ^2=8.073,P<0.01);观察组患者WBC、PLT计数及Hb含量均明显高于对照组(P<0.05);观察组治疗前后免疫功能指标CD4^+、CD8^+及CD4^+/CD8^+明显高于对照组,差异均有统计学意义(P<0.05)。结论HBO辅助治疗乳腺癌术后放化疗患者可明显提高其免疫功能指标,提高PLT、WBC计数及Hb含量,且术后并发症发生率明显降低,可在临床推广应用。

Objective To study the effects of hyperbaric oxygen(HBO)therapy on immune function and quality of life in patients with breast cancer undergoing radiochemotherapy.Methods A total of 100 breast cancer patients admitted in the Department of General Surgery of Fujian Provincial Hospital South Branch from the February of 2015 to the February of 2018 were selected as the study objects,and were divided into observation group and control group according to the random number table method,with 50 cases in each group.Patients in the control group were treated with chemoradiotherapy and other routine clinical symptomatic treatments.Patients in the observation group were treated with HBO therapy on the basis of the treatments of the control group.One week after treatment,the occurrence of ischemic necrosis of flap,subcutaneous hydrops,incision infection,and edema of the affected limbs were all evaluated and recorded.After 5 courses of treatment,the changes of WBC,PLT,hemoglobin content,and serum immune function indexes,CD4^+,CD8^+,and CD4^+/CD8^+of both the two groups before and after treatment were detected and compared.Results After 5 courses of treatment,the occurrence of ischemic necrosis of flap,subcutaneous hydrops,incision infection,and edema of the affected limbs of the observation group were significantly lower than those of the control group(χ^2=8.073,P<0.01).WBC and PLT counts,hemoglobin content in the observation group were significantly higher than those in the control group(P<0.05).Compared with the control group,CD4^+,CD8^+and CD4^+/CD8^+were significantly increased in the observation group(P<0.05).Conclusion HBO therapy can improve the immune function indexes of breast cancer patients after radiochemotherapy and increase PLT,WBC count,and hemoglobin content,so as to significantly reduce the incidence of postoperative complications,which is worthy of popularization and application in clinic.