肿瘤多药耐药与自噬、DNA修复和肿瘤干细胞相关的分子机制研究进展

Advances in Molecular Mechanisms Related to Tumor Multi-drug Resistance,Autophagy,DNA Repair and Tumor Stem Cells

肿瘤多药耐药(multi-drug resistance,MDR)所导致的化疗失败,依旧是肿瘤治疗中存在的难点。虽然针对MDR,已经成功开发了三代靶向三磷酸腺苷结合盒转运体(ATP binding cassette transporter,ABC)的抑制剂,也有MDR调节剂和化学增敏剂,多功能纳米载体和RNA干扰等方法可有效逆转MDR,但是由于肿瘤多药耐药机制的复杂性,MDR依然是肿瘤治疗中面临的难题。将从目前研究比较集中的ABC转运体异常表达;DNA损伤修复的改变和细胞凋亡的异常;自噬诱导与耐药及肿瘤干细胞与耐药等四方面入手,针对目前MDR机制的研究进展做一综述,旨在为MDR的研究提供思路和方法。

The failure of chemotherapy caused by tumor multi-drug resistance(MDR)is still a difficult point in tumor treatment.Although three generations of inhibitors have been successfully developed for MDR,targeting ATP binding cassette transporter(ABC),there are also effective methods to reverse MDR,such as MDR regulator or chemical sensitizer,multifunctional nanocarrier and RNA interference,but MDR is still a difficulty in tumor treatment due to the complexity of tumor multi-drug resistance mechanism.In this paper,we will focus on the abnormal expression of ABC transporter,The changes of DNA injury repair and apoptosis,autophagy induction and drug resistance,tumor stem cells and drug resistance were reviewed in order to provide ideas and methods for the study of MDR.