蛋白冠与纳米粒子的相互作用

Interaction between Protein Corona and Nanoparticles

近年来,尽管纳米粒子在生物医学领域的研究中取得了巨大的进展,但很少能进入临床试验阶段,其中,很大程度取决于人们缺乏对纳米粒子与生理环境之间相互作用的认知,对纳米粒子进入体内后的生物学特性了解有限。在生理环境下,蛋白质会吸附于纳米粒子表面,从而形成蛋白冠,这种纳米粒子-蛋白冠复合物的形成严重影响纳米粒子的生物学特性,限制了纳米粒子的临床应用,因此,蛋白质与纳米粒子之间的相互作用应该被深入研究。目前,对纳米粒子-蛋白冠复合物的研究属于一个相对较新的研究领域。概括了蛋白冠的研究现状,对蛋白冠与纳米粒子相互作用所产生的影响进行了重点阐述,也介绍了预防和减少蛋白冠形成的方法,为纳米粒子的进一步研发提供了思路。

In recent years,although nanoparticles have made great progress in biomedical research,they rarely enter clinical trials.This is mainly due to the lack of understanding of the interaction between nanoparticles and the physiological environment and the limited understanding of the biological characteristics of nanoparticles after they enter the body.In the physiological environment,proteins adsorb on the surface of nanoparticles and form protein corona.The formation of this nanoparticles-protein corona complex seriously affects the biological characteristics of nanoparticles and restricts the clinical application of nanoparticles.Therefore,the interaction between protein corona and nanoparticles should be further studied.At present,the research on nanoparticle-protein corona complex is a relatively new field.This review summarizes the research status of protein corona,and focuses on the impact of the interaction between protein corona and nanoparticles.It also introduces methods to prevent and reduce the formation of protein corona,providing ideas for further research and development of nanoparticles.