血必净减轻重度烧伤患者器官功能损害的临床研究

Clinical Study on Reducing Organ Function Damage in Severe Burn Patients

目的:研究血必净对重度烧伤患者的疗效及谷丙转氨酶(ALT)、谷草转氨酶(AST)、降钙素原(PCT)水平的影响。方法:选取我院2014年12月-2018年12月收治的重度烧伤患者102例,根据治疗方法不同均分为两组。对照组给予补液、创面处理、抗生素等常规对症治疗,观察组在常规对症治疗基础上给予血必净治疗,分析两组患者治疗后的疗效、ALT、AST、PCT、白细胞介素-1(IL-1)、脂质过氧化物(LPO)水平变化及全身炎症反应综合征(SIRS)、多脏器功能障碍综合征(MODS)的发生率。结果:观察组总有效率(82.35%)高于对照组(62.75%),SIRS发生率(33.33%)低于对照组(60.78%),但MODS发生率(15.69%)与对照组(21.57%)比较,差异无统计学意义(P>0.05)。两组治疗前ALT、AST、PCT、IL-1、LPO水平差异无统计学意义(P>0.05)。观察组治疗3天、7d后的ALT[(95.36±21.75)U/L、(61.25±10.14)U/L]、AST[(58.26±10.42)U/L、(45.36±9.98)U/L]、PCT[(3.26±0.36)ng/L、(1.45±0.22)ng/L]、IL-1[(129.02±12.63)ng/L、(118.55±10.42)ng/L]、LPO[(9.79±1.76)mg/L、(15.44±2.54)mg/L]水平低于对照组(P<0.05)。结论:血必净治疗重度烧伤可有效减轻器官功能的损害,降低SIRS的发生。

Objective To study the therapeutic effect of Xuebijing on severe burn patients and the change of procalcitonin(PCT),glutamic-pyruvic transaminase(ALT)and glutamic-oxalacetic transaminase(AST).Methods 102 patients with severe burn were selected from December 2014 to December 2018 and they were divided into two equal groups according to the treatment method.The control group was treated with fluid replacement,wound treatment,antibiotics and other routine symptomatic treatment,while the observation group was treated with Xuebijing on the basis of routine symptomatic treatment.The curative effect of the two groups was analyzed.The changes of ALT,AST,PCT,interleukin-1(IL-1),lipid peroxide(LPO)level,the incidence of systemic inflammatory response syndrome(SIRS)and multiple organ dysfunction syndrome(MODS)in systemic inflammatory response syndrome were analyzed.Results The total effective rate of observation group(82.35%)was higher than that of control group(62.75%).The incidence of SIRS in systemic inflammatory response syndrome(33.33%)was lower than that in control group(60.78%),but the incidence of MODS in multiple organ dysfunction syndrome(15.69%)was not significantly different from that in control group(21.57%).There was no significant difference in ALT,AST,PCT,IL-1,LPO level between the two groups before treatment(P>0.05).The levels of AST[(58.26±10.42),(45.36±9.98)]U/L and IL-1[(129.02±12.63),(118.55±10.42)]ng/L,LPO[(9.79±1.76),(15.44±2.54)]mg/L in the observation group were significantly lower than those in the control group[(129.02±12.63),(118.55±1.76),(15.44±2.54)]mg/L,and the levels were(3.26±0.36),(1.45±0.22)and(9.79±1.76),(15.44±2.54)respectively.After treatment for 3 days,and the relative levels were(3.26±0.36),(1.45±0.22)and(9.79±1.76),(15.44±2.54)respectively.Conclusion Xuebijing in the treatment of severe burn can effectively reduce the damage of organ function and reduce the occurrence of SIRS.