黄芪注射液对冠心病心绞痛患者血液流变学、免疫功能及血脂代谢的影响

Effects of Astragalus injection on hemorheology,immune function and blood lipid metabolism in patients with angina pectoris of coronary heart disease

目的通过观察黄芪注射液对冠心病心绞痛患者血液流变学、免疫功能及血脂代谢的影响,探讨黄芪注射液在冠心病心绞痛患者中的应用。方法选取陕西省咸阳市中心医院2017年6月至2018年12月收治的144例冠心病心绞痛患者,按照随机数字表法分为观察组与对照组,各72例。对照组给予常规治疗,观察组在常规治疗基础上加用黄芪注射液治疗。测定两组患者治疗前后血液流变参数(血细胞聚集指数、纤维蛋白原水平及血细胞黏滞度)、免疫功能(CD4^+、CD8^+、CD4^+/CD8^+)及血脂代谢情况[总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)]。结果血液流变参数对比:两组治疗后血细胞聚集指数、纤维蛋白原水平及血细胞黏滞度均较治疗前降低,且观察组治疗后各指标均低于对照组,差异均有统计学意义(P<0.05)。免疫功能对比:观察组治疗后CD4^+、CD4^+/CD8^+均较治疗前增加,差异均有统计学意义(P<0.05),观察组治疗后CD8^+与治疗前比较,差异无统计学意义(P>0.05);对照组治疗前后各指标比较,差异均无统计学意义(P>0.05);观察组治疗后CD4^+、CD4^+/CD8^+较对照组高,差异有统计学意义(P<0.05)。血脂代谢情况对比:观察组治疗后TC、TG、LDL-C水平均较治疗前降低,HDL-C水平较治疗前增加,且观察组治疗后TC、TG、LDL-C水平较对照组低,HDL-C水平较对照组高,差异均有统计学意义(P<0.05)。结论黄芪注射液可有效降低冠心病心绞痛患者血液凝集度,提高其免疫功能,并改善血脂代谢状况,临床推广价值较高。

Objective To investigate the application of Astragalus injection in patients with angina pectoris of coronary heart disease through observing the effects of Astragalus injection on hemorheology,immune function and blood lipid metabolism in patients with angina pectoris of coronary heart disease.Methods A total of 144 patients with angina pectoris of coronary heart disease who were admitted to the Xianyang Central Hospital from June 2017 to December 2018 were selected and randomly divided into the observation group and the control group,72 cases in each group.The control group was given routine treatment,and the observation group was treated with Astragalus injection on the basis of routine treatment.Hemorheological parameters(blood cell aggregation index,concentration of fibrinogen and blood cell viscosity),immune function(CD4^+,CD8^+and CD4^+/CD8^+)and lipid metabolism(TC,TG,LDL-C and HDL-C)in both groups were determined before and after treatment.Results The hemorheological parameters(blood cell aggregation index,fibrinogen concentration and blood cell viscosity)in both groups decreased after treatment,and the levels were lower in the observation group than those in the control group(P<0.05).CD4^+and CD4^+/CD8^+in the observation group were significantly increased after treatment(P<0.05),but there was no change in CD8^+(P>0.05).There was no significant difference in the indexes in the control group before and after treatment(P>0.05).After treatment,CD4^+and CD4^+/CD8^+were higher in the observation group than those in the control group(P<0.05).After treatment,the levels of TC,TG and LDL-C in the observation group decreased,while the level of HDL-C increased.Besides,the levels of TC,TG and LDL-C were lower in the observation group than those in the control group,while the level of HDL-C was higher than that in the control group after treatment,and the difference were statistically significant(P<0.05).Conclusion Astragalus injection can effectively reduce the blood agglutination,and improve the immune function and blood lipid metabolism in patients with angina pectoris of coronary heart disease.