氨甲环酸片联合2%氢醌乳膏对黄褐斑患者复发率的影响

Effect of tranexamic acid tablets combined with 2%hydroquinone cream on recurrence rate of patients with chloasma

目的探讨氨甲环酸片联合2%氢醌乳膏对黄褐斑患者复发率的影响。方法选取2017年8月-2018年5月于我院接受治疗的61例黄褐斑患者,依据盲抽法分为对照组(n=30)与观察组(n=31)。两组均予以常规治疗,对照组予以2%氢醌乳膏治疗,观察组在对照组基础上加用氨甲环酸片治疗,比较两组临床疗效、症状积分、黄褐斑皮损面积和严重程度指数(MASI)评分、皮肤色斑变化率、患者自我满意度、复发率及不良反应发生率。结果与对照组总有效率73.33%相比,观察组96.77%高,差异有统计学意义(P<0.05);治疗后,两组症状积分与MASI评分均较治疗前低,且观察组较对照组低,差异有统计学意义(P<0.05);治疗3个月后,与对照组患者自我治疗总满意率70.00%相比,观察组96.77%高,差异有统计学意义(P<0.05);与对照组复发率30.00%相比,观察组6.45%低,差异有统计学意义(P<0.05);与对照组不良反应发生率10.00%相比,观察组6.45%略低,但差异不显著(P>0.05)。结论黄褐斑患者采用氨甲环酸片联合2%氢醌乳膏治疗效果显著,可有效改善患者临床症状,减少皮损面积,促进其皮肤色斑恢复,且复发率低,安全性高,有利于提升患者自我治疗满意度。

Objective To investigate the effect of tranexamic acid tablets combined with 2%hydroquinone cream on the recurrence rate of patients with chloasma.Methods 61 patients with chloasma who were treated in our hospital from August 2017 to May 2018 were selected and divided into a control group(n=30)and an observation group(n=31)according to blind sampling method.Both groups were treated routinely,and the control group was treated with 2%hydroquinone cream,the observation group was treated with tranexamic acid tablets on the basis of the control group.The clinical efficacy,symptom score,chloasma lesion area and severity Index(MASI)score,skin stain change rate,patient self-satisfaction,relapse rate and incidence of adverse reactions of the two groups were compared.Results Compared with the total effective rate of 73.33%in the control group,the observation group’s rate 96.77%was higher,the difference was statistically significant(P<0.05);after treatment,the symptom scores and MASI scores in both groups were lower than before treatment,and the observation group was lower than the control group,the di fference was statistically signi ficant(P<0.05);after 3 months of treatment,compared with the total self-treatment satisfaction rate of 70.00%in the control group,the observation group’s rate 96.77%was higher,the di fference was statistically signi ficant(P<0.05);Compared with the control group recurrence rate of 30.00%,the observation group was 6.45%lower,the difference was statistically significant(P<0.05);compared with the control group incidence of adverse reactions of 10.00%,the observation group was slightly lower 6.45%,but the di fference was not statistically signi ficant(P>0.05).Conclusion The treatment of melasma patients with tranexamic acid tablets combined with 2%hydroquinone cream has a significant effect,which can effectively improve the clinical symptoms of patients,reduce the area of skin lesions,and promote the recovery of skin spots,with a low recurrence rate and high safety and is conducive to improving patient self-treatment satisfaction.