多种途径应用氨甲环酸联合治疗黄褐斑的研究进展

Progress of tranexamic acid combination therapy For Melasma

黄褐斑是一种临床常见的损容性皮肤疾病,因黑色素生成障碍导致局部、慢性获得性皮肤色素增加。它对患者的外貌有很大的不良影响,会造成心理和情绪上的痛苦,降低患者的生活质量。氨甲环酸是一种纤溶酶抑制剂,其通过抑制酪氨酸酶的活性和黑素小体的转运来达到治疗黄褐斑的目的。本文旨在回顾近年来氨甲环酸通过口服、外用和皮内注射等多种途径联合激光、药物治疗黄褐斑,以期为黄褐斑的临床治疗提供更多的思路。

Melasma is a common clinical lesions of skin disease, due to melanin production disorders lead to local, chronic acquired skin pigment increase.It has a great negative impact on the appearance of patients, will cause psychological and emotional pain, reduce the quality of life of patients.Tranexamic acid is a plasmin inhibitor , which can treat melasma by inhibiting the activity of tyrosinase and the transport of melanosomes.The purpose of this paper is to review recent years of treatment of melasma by tranexamic acid combined with laser and drug through oral, external and intradermal injection, so as to provide more ideas for clinical treatment of melasma.