缺氧诱导因子通路在骨发育中的作用及研究进展

Advances and role of hypoxia-inducible factor in bone development

缺氧诱导因子是氧依赖性的转录激活因子,在血管生成、红细胞生成、能量代谢和细胞周期中起着至关重要的作用。骨髓是缺氧微环境,富含生长因子、血管丰富,骨髓的缺氧水平可诱导缺氧诱导因子通路,该通路对骨发育有着深远的影响。目前已知缺氧诱导因子在骨发育的过程中可以调节多种蛋白和信号通路,而这些蛋白和信号通路大多能对细胞的分化、增殖及功能进行调节。本文综述缺氧诱导因子通路在骨发育中的作用及研究进展,从而进一步探讨缺氧诱导因子在骨发育调控中的机制。

Hypoxia inducible factor is an oxygen dependent transcriptional activator,which plays an important role in angiogenesis,erythropoiesis,energy metabolism and cell cycle.Bone marrow is a hypoxia microenvironment,rich in growth factors and blood vessels.The hypoxia level of bone marrow can induce hypoxia signal pathway,which has a profound impact on bone development.At present,it is known that Hypoxia inducible factor can regulate a variety of protein and signal pathways in the process of bone development,and most of these protein factors and signal pathways can regulate cell differentiation,proliferation and function.This paper reviews the role and research progress of hypoxia regulatory factor pathway in bone development,so as to further explore the mechanism of Hypoxia inducible factor in bone development regulation.