慢性鼻窦炎手术前后嗅觉功能变化的影响因素研究

Study on the influencing factors of olfactory function changes before and after surgery for chronic rhinosinusitis

目的研究慢性鼻窦炎嗅觉障碍的影响因素,内镜鼻窦手术后主观嗅觉功能变化情况。方法回顾分析126例慢性鼻窦炎经鼻内镜鼻窦手术后SNOT-22量表中嗅觉功能评分改善情况,采用多元线性回归分析嗅觉障碍的影响因素,采用相关系数分析术前Lund-Kennedy内镜评分与术前嗅觉评分的关系。结果 126例慢性鼻窦炎中115例(91.3%)出现嗅觉障碍,其中92例(80.0%)术后主观嗅觉功能改善。饮酒、吸烟、哮喘、修正手术,外周血嗜酸性粒细胞比例≥6影响慢性鼻窦炎术前嗅觉评分(P<0.1),术前Lund-Kennedy内镜评分与嗅觉评分具有相关性(P<0.05)。结论多种因素可能影响慢性鼻窦炎患者的嗅觉功能,内镜鼻窦手术可以提高慢性鼻窦炎患者的嗅觉功能。

Objective To study the influencing factors of olfactory function changes before and after endoscopic sinus surgery(ESS)for chronic rhinosinusitis(CRS).Methods Subjective olfactory function based on SNOT-22 scores was retrospective analyzed in 126 cases of CRS before and after ESS.Clinical factors affecting olfactory function with CRS were analyzed with multiple linear regressions.Relationship between Lund-Kennedy endoscopic scores and olfactory scores was analyzed with Coefficient Correlation.Results In total of 126 cases with CRS there were 115 cases(91.3%)complained of dysosmia,in which olfactory scores of 92 cases(80.0%)increased after ESS.Alcohol drinking,smoking,asthma,reversion surgery and the proportion of eosinophils in peripheral blood≥6 affected olfactory scores in patients with CRS(P<0.1).Lund-Kennedy endoscopic scores correlated with olfactory scores in patients with CRS before surgery(P<0.05).Conclusions Several factors may affect olfactory function in patients with CRS.ESS may improve olfactory function in patients with CRS.