使用3-甲基吲哚制作嗅觉障碍模型的研究进展

Research Progress in the use of 3-methylindole as a moder of oltactory dysfunction

嗅觉障碍是指在气味感受、传导及信息分析整合过程中,嗅觉通路在各环节发生器质性和功能性病变,导致气味感知异常。目前主要通过局部或全身给药来制作嗅觉障碍的动物模型,3-甲基吲哚就是其中一种代表性药物。3-甲基吲哚可以通过与鲍曼氏腺细胞和支持细胞表面的细胞色素P450酶的同工酶2G1、2A10和2A11结合来生成一种嗅觉毒性物质,从而使动物达到嗅觉障碍的效果。本文主要总结了3-甲基吲哚导致嗅觉障碍的机理和使用3-甲基吲哚制造嗅觉障碍动物模型的研究现状并对其存在的问题进行了讨论,以期为使用3-甲基吲哚制造嗅觉障碍动物模型的研究提供参考。

Olfactory dysfunction refers to the olfactory pathway in the process of integration of odor perception,conduction and information analysis.The olfactory pathway generates qualitative and functional lesions in all links,resulting in abnormal odor perception.At present,animal models of olfactory disorders are mainly produced by local or systemic administration,and 3-methylindole is one of the representative drugs.3-methylindole can form an olfactory toxic substance by binding to Bowman's gland cells and isoenzymes that support the cell surface cytochrome P450 enzyme 2G1、2A10 and 2A11,thereby allowing the animal to achieve olfactory disorders.This paper summarizes the mechanism of 3-methylindole-induced olfactory disorders and the research status of animal models of olfactory disorders using 3-methylindole,as well as its existing problems.This paper also try to provide a reference for the study of animal models of olfactory disorders using 3-methylindole.