壳聚糖温敏水凝胶研究进展

Research Progress in Chitosan Thermosensitive Hydrogel

温敏性水凝胶是一种智能型高分子水凝胶,能在应答外界温度刺激时发生自身相变,具有良好的生物相容性与力学性能,被广泛应用于组织工程、细胞包封、药物传递等方面。壳聚糖是一种在自然界中大量存在的多糖,因具有低细胞毒性与生物相容性,常作为药物缓释体被广泛应用。重点对近几年壳聚糖温敏水凝胶的相关研究进行综述。

Thermosensitive hydrogel is an intelligent polymer hydrogel which can generate its own phase transition in response to external temperature stimulation.It has good biocompatibility and mechanical properties,which is widely used in tissue engineering,cell encapsulation,drug delivery and so on.Chitosan is a kind of polysaccharide in nature.Because of its low cytotoxicity and biocompatibility,it is often used as a drug delivery system.The research on chitosan thermosensitive hydrogel in recent years is reviewed.