斑块微环境与中医阴阳学说的关系

The Relationship between Plaque Microenvironment and the Yin-Yang Theory in Traditional Chinese Medicine

动脉粥样硬化斑块的形成、发展与机体和局部的内环境密切相关。斑块微环境既包括组成斑块本身的细胞成分及其分泌的因子,也包括存在于微环境中的促进斑块形成的各种病理因素。中医学认为,阴阳平衡是维持人体正常生命活动的基础,而斑块的形成是其微环境阴阳消长失衡的结果;当微环境中各种阴阳属性的因子过度转化时,则进一步加剧失衡状态,最终走向阴阳格拒,导致斑块破裂。中医药因其多靶点的调节作用,在维持机体阴阳平衡中具有显著的效果,而恢复疾病状态下的阴阳动态平衡是治疗动脉粥样硬化斑块的基本准则。

The formation and development of atherosclerotic plaques are closely related to the local internal environment of the body.The plaque microenvironment includes the cellular components that make up the plaque itself and the factors secreted by them,as well as various pathological factors that exist in the microenvironment to promote plaque formation.In Chinese medicine,the balance of yin and yang is the basis for maintaining the normal life activities of the human body,and the formation of plaque is the result of the imbalance of yin and yang in its micro-environment.When the factors of various yin and yang properties in the micro-environment are over-converted,the unbalanced state is further aggravated,and finally the yin-yang rejection is caused,resulting in plaque rupture.Due to its multi-target regulation,traditional Chinese medicine has a significant effect in maintaining the balance of yin and yang in the body.Restoring the dynamic balance of yin and yang under disease state is the basic criterion for the treatment of atherosclerosis.