盐酸多奈哌齐联合尼麦角林治疗阿尔茨海默病临床疗效观察

Clinical Efficacy of Donepezil Hydrochloride Combined with Nimodipine in the Treatment of Elderly Patients with Alzheimer's Disease

[目的]探讨盐酸多奈哌齐联合尼麦角林治疗阿尔茨海默病(AD)老年患者的临床疗效.[方法]回顾性分析2015年6月至2018年1月在本院诊治的115例AD老年患者,根据治疗方法分为观察组(n=65)和对照组(n=50).对照组采用尼麦角林治疗,观察组采用在对照组基础上加用盐酸多奈哌齐治疗.两组治疗1个月,比较两组患者疗效和治疗前后血清高半胱氨酸(Hcy)、神经元特异性烯醇化酶(NSE)、中枢神经元特异性蛋白(S100β)、Orgotein(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、脂质氧化终产物丙二醛(MDA)水平及不良反应发生率.[结果]观察组患者总有效率为92.31%,显著高于对照组(78.00%),其差异有统计学意义(P<0.05).治疗前,两组患者血清Hcy、NSE、S100β水平比较差异无统计学意义(P>0.05);治疗后,两组患者血清Hcy、NSE、S100β、MDA水平降低(P<0.05),SOD、GSH-Px水平增加,观察组患者SOD、GS H-Px水平显著高于对照组(P<0.05),且观察组变化更为明显.观察组总不良反应发生率为6.15%,显著低于对照组的22.00%,其差异有统计学意义(P<0.05).[结论]盐酸多奈哌齐联合尼麦角林治疗治疗AD老年患者,疗效显著,能显著降低患者血清Hcy、NSE、S100β水平,调节SOD、GSH-Px及MDA水平,且具有较高的安全性,值得临床推广使用.

[Objective]To investigate the effect of donepezil hydrochloride combined with nicergoline on the efficacy and stress status of elderly patients with Alzheimer's disease.[Methods]A retrospective analysis was made of 115 elderly patients with AD who were treated in our hospital from June 2015 to January 2018.According to the treatment methods,they were divided into observation group(n=65)and control group(n=50).The control group was treated with nimodipine,and the observation group was treated with donepezil on the basis of the control group.After treatment for one month,the therapeutic effect and the levels of serum homocysteine(Hcy),neuron specific enolase(NSE),central neuron specific protein(S100β),orgotein(SOD),glutathione peroxidase(GSH Px),malondialdehyde(MDA),the end product of lipoxygenation,and the incidence of adverse reactions were compared.[Results]The total effective rate of the observation group was 923.1%,which was significantly higher than that of the control group(78.00%)(P<0.05).Before treatment,there was no significant difference in serum Hcy,NSE and S100βlevels between the two groups(P>00.5);after treatment,the serum Hcy,NSE,S100βand MDA levels of the two groups decreased(P<00.5),SOD and GSH Px levels increased,SOD and GSH PX levels of the observation group were signifi‐cantly higher than those of the control group(P<0.05),and the changes of the observation group were more obvious.The total incidence of adverse reactions in the observation group was 61.5%,which was signifi‐cantly lower than that in the control group(220.0%)(P<00.5)[Conclusion]Donepezil hydrochloride com‐bined with nimodipine in the treatment of elderly patients with AD has a significant effect,can significantly re‐duce the level of Hcy,NSE,S100β,regulate the level of SOD,GSH Px and MDA,and has a high safety,which is worthy of clinical application.