虾青素的检测及生物活性研究进展

Research progress on detection and biological activity of astaxanthin

虾青素是一种酮式类胡萝卜素,在体内外均有潜在的生物活性,是目前已知抗氧化能力最强的天然抗氧化剂,有"超级维生素E"之称。虾青素具有共轭双键长链结构,在长链的2端有羟基和羰基基团,使其易被氧化,因此具有强大的抗氧化能力,可淬灭单线态氧、清除自由基、防止或终止因单线态氧和自由基引起的链式反应。本文就虾青素的结构特点、生物体内代谢和检测方法,以及抗氧化、抗炎和抗凋亡的生物活性在缺血再灌注损伤、神经变性疾病、皮肤损伤和胃部炎症的具体疾病预防与保护中的运用展开论述。在现有研究的基础上,以期为虾青素的深入研究提出新思路,使其潜在的巨大价值得到开发利用。

Astaxanthin is a keto-carotenoid with potential bioactivity in vitro and in vivo.It is known to be the most powerful natural antioxidant which called "super vitamin E".Astaxanthin has conjugated long chain double bond structure with hydroxyl and carbonyl groups at both ends of the long chain,which makes it easy to be oxidized,so it has strong antioxidant capacity,including quenching singlet oxygen,scavenging free radicals,and preventing or terminating chain reactions caused by singlet oxygen and free radicals.In this paper,the structural characteristics,the metabolism and detection methods of astaxanthin,and the application of antioxidant,anti-inflammatory and anti-apoptotic biological activities in the prevention and protection of specific diseases of ischemia-reperfusion injury neurodegenerative diseases,skin injury and stomach inflammation are discussed.Based on the existing research,to put forward new ideas for in-depth research of astaxanthin,so that its potential huge value can be developed and utilized.