摘要
病理性瘢痕一般是各种皮肤创伤后机体异常修复的结果,特征性表现为异常的成纤维细胞增生及细胞外基质沉积。近年来,多项研究证实自体脂肪注射物含有多种可能与治疗瘢痕相关的物质,如基质血管片段、脂肪来源间充质干细胞等,这些物质可通过相关通路抑制成纤维细胞的过度增生和胶原沉积,从而改善病理性瘢痕的进展及预后。临床研究显示,脂肪注射物可以改善病理性瘢痕的厚度、颜色、柔软度和局部症状。更加深入地了解脂肪组织抗纤维化的机制,将有助于病理性瘢痕治疗技术的发展。
Pathological scars mostly result from abnormal remodeling after skin trauma,and they are characterized by dysregulated fibroblast proliferation and extracellular matrix deposition.In recent years,several studies have confirmed that autologous fat injections contain a variety of substances that may be involved in the treatment of scars,such as stromal vascular fraction,adipose-derived mesenchymal stem cells and so on.These substances can inhibit the excessive proliferation of fibroblasts and deposition of collagen through related pathways,so as to slow the progression and improve the prognosis of pathological scars.Clinical studies have demonstrated that fat injections can effectively ameliorate the thickness,color,softness and local symptoms of pathological scars.Further understanding of the anti-fibrosis mechanism of adipose tissues will facilitate the development of therapies for pathological scars.
作者
王浦
秦泽莲
Wang Pu;Qin Zelian(Department of Plastic and Reconstructive Surgery,Peking University Third Hospital,Beijing 100191,China)
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2020年第6期473-475,共3页
Chinese Journal of Dermatology
基金
国家自然科学基金(81772090)。
关键词
瘢痕
脂肪组织
干细胞移植
脂肪间充质干细胞
Cicatrix
Adipose tissue
Stem cell transplantation
Adipose-derived mesenchymal stem cells