药物诱发大疱性类天疱疮的研究进展

Drug-induced bullous pemphigoid

药物诱发大疱性类天疱疮(BP)是指由系统或局部用药后诱发的一种特殊类型BP。对所有新发或是突然加重的BP患者,应警惕药物诱发的可能性,特别是近年报道较多的疫苗接种及二肽基肽酶4抑制剂、肿瘤坏死因子α拮抗剂和程序性死亡受体1/程序性死亡配体1抑制剂等新型药物。本文综述近年来药物诱发BP的研究进展。

Drug-induced bullous pemphigoid(BP)is a special type of BP,and is commonly induced by systemic or topical administration of drugs.For all the patients with newly emerging or rapidly aggravated BP,attention should be paid to the possibility of drug induction,especially vaccines and some novel drugs such as dipeptidyl-peptidase-4 inhibitors,tumor necrosis factor-α antagonist,and programmed death receptor-1/programmed death ligand-1 inhibitor,which have been frequently reported in recent years.This review summarizes research advances in drug-induced BP in recent years.