甲状腺激素——临床应用70年

Thyroid hormones--Seven decades of clinical application

自1949年甲状腺素钠盐合成以来,人工合成的甲状腺激素用于甲状腺功能减退症(甲减)治疗已经有70年历史。这些年中,甲状腺激素制剂从干甲状腺提取物到左甲状腺素钠(L-T4),L-T4制剂的质量标准从宽到窄,临床应用上L-T4剂量越来越个体化,L-T4/L-T3联合治疗也有了更多的循证医学证据。在回顾和分析现有文献基础上,本文围绕甲状腺激素制剂及其临床应用发展历史展开综述。

Synthetic thyroid hormones have been used in the treatment of hypothyroidism for 70 years since the synthesis of thyroxine sodium salt in 1949.There have been accumulated evidences for the facts that levothyroxine sodium(L-T4)replaces the desiccated thyroid extracts as the mainstay of thyroid hormone preparation,the specifications for L-T4 preparations change from loose to strict,L-T4 dosage is increasingly individualized in clinical application,as well as the combined treatment with L-T4/L-T3.Based on the review and analysis of the existing literature,our review is tried to summarize the development history of thyroid hormone preparation and its clinical application.