尿酸与认知功能障碍关系的研究进展

The association between serum uric acid and cognitive dysfunction

随着老龄化进程加快,认知功能障碍已经成为亟待解决的公共卫生问题。近年来提出认知功能障碍的发生发展与氧化应激密切相关,而尿酸作为体内重要的抗氧化剂,可能具有相应的认知保护功能。但也有学者认为,尿酸可能是认知功能恶化的危险因素。尿酸作用机制的多样性及不同认知功能障碍的病理生理特征,导致了尿酸与不同类型认知功能障碍间的关系具有复杂性与争议。本文将就尿酸对不同认知功能障碍的影响及其可能机制作一综述,旨在通过对尿酸与认知功能障碍之间关系的深入理解,更好地指导临床工作。

As the aging process accelerates,cognitive dysfunction has become a significant public health problem.Recently,oxidative stress has been recognized as a critical factor contributing to the pathogenesis of cognitive dysfunction.Therefore,uric acid,as an important antioxidant in vivo,might correspondingly play cognitive protection roles.However,uric acid was regarded as a risk factor for cognitive deterioration in some studies.The uric acid paradox,together with the pathophysiological differences between cognitive disorders,adds to the complexity of their association.So far,the impact of uric acid on cognitive function has been debated.This article tried to review the impact of uric acid on different cognitive disorders and to discuss the possible mechanisms.