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酚妥拉明联合钙通道阻滞剂治疗妊娠期高血压患者的疗效评价

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摘要 目的 观察酚妥拉明联合钙通道阻滞剂硝苯地平治疗妊娠期高血压(GH)患者的疗效评价.方法 选取郑州颐和医院2016年7月-2018年6月98例GH患者,按照治疗方法分为两组,各49例.对照组予以硝苯地平治疗,观察组在对照组基础上予以酚妥拉明治疗.对比两组临床疗效,治疗前、治疗10d后收缩压(SBP)、舒张压(DBP)、血清一氧化氮(NO)、内皮素-1(ET-1)水平及妊娠结局.结果 观察组治疗总有效率87.76%(43/49)高于对照组69.39%(34/49)(P<0.05);治疗前两组SBP、DBP对比,差异无统计学意义(P>0.05),治疗10 d后观察组SBP、DBP低于对照组(P<0.05);治疗前两组血清NO、ET-1水平对比,差异无统计学意义(P>0.05),治疗10 d后观察组血清NO水平高于对照组,血清ET-1水平低于对照组(P<0.05);观察组剖宫产率30.61%(15/49)低于对照组51.02%(25/49),新生儿不良结局发生率18.37%(9/49)低于对照组36.73%(18/49)(P<0.05).结论 酚妥拉明联合硝苯地平治疗GH患者,可提高治疗效果,调节NO与ET-1平衡,降低血压,改善母婴结局.
作者 于哲
出处 《临床研究》 2020年第7期41-43,共3页 Clinical Research
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