玉米赤霉烯酮和脱氧雪腐镰刀菌烯醇对动物毒性的研究进展

Research Progress on Toxicity of Zearalenone and Deoxynivalenol in Animals

玉米赤霉烯酮(ZEA)和脱氧雪腐镰刀菌烯醇(DON)是镰刀菌产生的毒素,广泛存在于霉变的玉米、小麦、大麦、燕麦和高粱等谷物中。自然条件下ZEA和DON经常混合污染饲粮、饲料原料乃至人类的食物,由于其高发生率和高毒性已严重威胁畜禽生产和人类健康,造成严重的经济损失和生命安全威胁。本文综述了ZEA和DON及其联合作用的生殖毒性、肠道毒性、免疫毒性、遗传毒性及致癌性,以期提高人们对其毒性的认识,避免畜禽养殖过程中ZEA和DON的毒害。

Zearalenone(ZEA)and deoxynivalenol(DON)are produced by a variety Fusarium species,and widespread in moldy grain such as corn,wheat,barley,oats and sorghum et al.Under natural conditions,ZEA and DON often mix to pollute diet,feed materials and even human food,the high incidence and high tox⁃icity of ZEA and DON constitute a serious threat to the animal,s production performance and human health,led to serious economic loss and life security threat.This review summarizes the toxicities of ZEA and DON and their combined effect as reproductive toxicity,intestinal toxicity,immune toxicity,genotoxicity and carci⁃nogenicity,in order to improve people’s understanding of its toxicity,and to avoid the poison of ZEA and Don in the process of livestock breeding.