临床药师参与癌痛规范化治疗的实践效果评价

Evaluation of the Participation of Clinical Pharmacists in Standardized Treatment of Cancer Pain

目的通过临床药师参与癌痛患者的规范化治疗,观察临床药师在治疗中的作用。方法选取2019年3月1—31日治疗的癌痛患者100例,根据临床药师是否参与癌痛治疗分为研究组和对照组,每组50例。对照组临床药师不参与癌痛治疗,研究组临床药师参与癌痛治疗。记录2组疼痛数字评价量表(NRS)、Morisky服药依从性量表(MMAS-8)、卡氏行为状态(KPS)评分,并分析不良反应情况。结果治疗24、48、72 h后,2组疼痛NRS评分均明显低于治疗前,且研究组明显低于对照组(P<0.01或P<0.05)。治疗72 h后,研究组疼痛完全缓解与明显缓解的总缓解率显著高于对照组(P<0.01)。治疗1周后,研究组的KPS评分改善程度显著优于对照组(P<0.01)。研究组入院1周后的MMAS-8评分明显高于入院时(P<0.05)。2组便秘发生率比较差异无统计学意义(P>0.05)。结论临床药师参与的癌痛规范化管理可明显提高患者服药依从性以及生存质量,缓解癌痛,在癌痛的规范化管理中起到积极的作用。

Objective To observe the role of clinical pharmacists in cancer pain treatment by involving clinical pharmacists in the standardized management of cancer pain.Methods A total of 100 patients with cancer pain treated from March 1,2019 to March 31,2019 were selected and divided into research group(n=50)and control group(n=50)according to participation of clinical pharmacists in cancer pain treatment.The clinical pharmacists in the control group did not participate in the treatment of cancer pain,while the clinical pharmacists in the research group participated in the treatment of cancer pain.Pain numeric rating scales(NRS),8-item Morisky medication adherence scale(MMAS-8),and Karnofsky performance status(KPS)score were recorded,and adverse reactions were analyzed.Results At 24,48,and 72 h after treatment,the pain NRS scores of the two groups were significantly lower than those before treatment,and were significantly lower in the research group than in the control group(P<0.01 or P<0.05).At 72 h after treatment,the total remission rate of pain complete relief and obvious relief in the research group was significantly higher than that in the control group(P<0.01);At 1 week after treatment,the improvement of KPS score in the research group was significantly better than that in the control group(P<0.01).The MMAS-8 score of the research group at 1 week after admission was significantly higher than that at admission(P<0.05).There was no significant difference in the incidence of constipation between the two groups(P>0.05).Conclusion The standardized management of cancer pain with the participation of clinical pharmacists can significantly improve patient compliance and quality of life,relieve cancer pain,which plays an active role in the standardized management of cancer pain.