APPL1在心肌缺血再灌注损伤中作用的研究进展

Research progress of APPL1 in myocardial ischemia reperfusion injury

体外循环(CPB)是心血管疾病心内直视手术中的必要技术,心肌缺血再灌注损伤(MIRI)是术后心功能障碍的主要原因之一。近年来,研究发现脂联素受体1结合蛋白(APPL1)不仅可以通过调节心肌的糖脂代谢、增加胰岛素敏感性、改善胰岛素抵抗来减轻MIRI,而且可以通过增加抗心肌细胞凋亡发挥减轻MIRI的保护作用。现就APPL1在MIRI的作用及其机制作一综述,为临床防治MIRI寻求新的靶点提供思路。

Cardiopulmonary bypass(CPB)is an essential technique in heart surgery for cardiovascular disease.Myocardial ischemia-reperfusion injury(MIRI)is the main cause of cardiac dysfunction after such surgery.In recent years,it has been found that adiponectin receptor 1 binding protein(APPL1)could reduce MIRI and protect the myocardium for MIRI by not only regulating myocardial glucose and lipid metabolism,increasing insulin sensitivity and alleviating insulin resistance and MIRI,but also increasing anticardiomyocyte apoptosis.Therefore,this article reviewed the role of APPL1 in myocardial ischemia-reperfusion injury and its potential mechanisms,and provided ideas for seeking new targets for clinical prevention or treatment of MIRI.