交变磁场与褪黑素对阿尔茨海默病患者睡眠障碍及昼夜节律失调中的作用

Efficacy of alternating magnetic field and melatonin on sleep disorders and circadian rhythm disorders in patients with alzheimer’s disease

目的:探讨交变磁场与褪黑素对阿尔茨海默病(Alzheimer’s Disease,AD)患者睡眠障碍(Sleep Disorders,SD)及昼夜节律失调(Circadian Rhythm Disorders,CRD)中的作用。方法:选取本院2016年1月-2019年1月收治的经病理学确诊的AD患者101例按随机数字表法(Random Number Table Method,RNTM)将其分成A、B组,各51例、50例,A组予以交变磁场与褪黑素联合治疗,B组单纯予以奥氮平治疗,用SPSS21.0软件处理两组各项SD、CRD临床指标。结果:A组治疗后的0、4、8、12、16、20等6个定向昼夜时点平均节律均高于B组(P<0.05);血清钙浓度均低于B组(P<0.05);两组治疗前、治疗时和随访期的夜间总睡眠时间与效率,入睡后觉醒时间与觉醒比,日间睡眠时间与效率,日间小睡平均时间比较(P<0.05),治疗前与治疗后A组以上指标和振幅,峰值时相,谷值比较无显著差异(P>0.05)。结论:在AD患者的临床治疗中予以交变磁场与褪黑素不会影响其SD,但能明显的改善其CRD,有较好的临床应用价值。

Objective:To investigate clinical efficacy of alternating magnetic field and melatonin on sleep disorders and circadian rhythm disorders in patients with alzheimer’s disease.Methods:From January 2016 to January 2019,101 cases were randomly divided into groups A and B,51 cases and 50 cases,respectively.The group A was treated by alternating magnetic field and melatonin,and the group B was treated with olanzapine.The clinical indicators of SD and CRD in two groups were processed by SPSS21.0 software.Results:6 directional day and night time points such as 0,4,8,12,16,20 after treatment,the average rhythm of the group A was higher than that in the group B(P<0.05);and the serum calcium concentration was lower(P<0.05).Before,during and follow-up,there was a significant difference in the total sleep time and efficiency at night,the awake time and arousal rate after falling asleep,the daytime sleep time and efficiency,and the average daytime napping time between the two groups(P<0.05).Between before and after treatment,there was no significant difference in the above indicators and amplitude,peak phase,and valley value in the group A(P>0.05).Conclusion:Alternating magnetic field and melatonin on AD will not affect the SD of patients,but it can significantly improve CRD and have good clinical application value.