艾司西酞普兰治疗青年卒中后抑郁效果观察

Efficacy of Escitalopram in the Treatment of Post-Stroke Depression of Youth

目的:探讨艾司西酞普兰治疗青年卒中后抑郁的临床效果.方法:选取2016年4月-2018年12月本院收治的50例青年卒中后抑郁患者,按随机数字表法分为对照组与观察组,每组各25例.对照组给予神经内科常规药物和神经功能康复治疗;观察组在对照组的基础上给予艾司西酞普兰抗抑郁治疗.于治疗前、治疗2周及4周后采用汉密尔顿抑郁量表(HAMD-17)、改良巴氏指数(MBI)、美国国立卫生研究院卒中量表(NIHSS)评分比较两组抑郁程度、日常生活活动能力及神经功能缺损程度.结果:治疗2、4周后,两组HAMD-17和NIHSS评分均低于治疗前,且观察组HAMD-17和NIHSS评分均低于对照组(P<0.05).治疗2、4周后,两组MBI评分均高于治疗前,且观察组MBI评分高于对照组(P<0.05).结论:艾司西酞普兰治疗青年卒中后抑郁有利于患者抑郁症状的改善和神经功能康复,可提高患者的生活质量,值得临床推广.

Objective:To investigate the clinical effect of Escitalopram in the treatment of post-stroke depression of youth.Method:A total of 50 patients with post-stroke depression of youth admitted to our hospital from April 2016 to December 2018 were selected.According to the random number table method,they were divided into control group and observation group,25 cases in each group.The control group was treated with conventional medicine and neurological rehabilitation.The observation group was treated with Escitalopram on the basis of the control group.Before treatment,after 2 and 4 weeks of treatment,the degree of depression,activities of daily living and neurological impairment were compared between the two groups by Hamilton depression rating scale(HAMD-17),modified Barthel index(MBI)and national institutes of health stroke scale(NIHSS)scores.Result:After 2 and 4 weeks of treatment,HAMD-17 and NIHSS scores in both groups were lower than those before treatment,and HAMD-17 and NIHSS scores in the observation group were lower than those in the control group(P<0.05).After 2 and 4 weeks of treatment,MBI scores in both groups were higher than before treatment,and MBI scores in the observation group were higher than those in the control group(P<0.05).Conclusion:The treatment of post-stroke depression of youth with Escitalopram is beneficial to the improvement of depression symptoms and the rehabilitation of neurological function in patients.It can improve the quality of life of patients,which is worthy of clinical promotion.