组织工程技术修复关节软骨缺损的研究进展

Advances in the Repair of Articular Cartilage Defects by Tissue Engineering Techniques

关节软骨缺损的再生修复是现代骨科临床面临的巨大挑战之一。由于软骨组织的无血管性质,其再生或修复能力有限,因此需要适当的材料系统,在物理、机械、组织学和生物学方面重新调整天然软骨组织的功能,促进软骨再生。目前包括基因治疗在内的组织工程技术正在成为软骨治疗的关键方法之一,并且为许多软骨创伤和疾病的治疗带来了新的曙光和更好的结果。本文综述和总结了组织工程技术在治疗关节软骨缺损方面的研究进展。

The regeneration and repair of articular cartilage defects is one of the great challenges faced by clinicians.Due to the vaseless nature of cartilage tissue,its ability to regenerate or repair is limited,and appropriate material systems are needed to facilitate cartilage regeneration by physically,mechanically,histologically,and biologically readjusting the function of natural cartilage tissue.At present,tissue engineering techniques including gene therapy are becoming one of the key methods of cartilage therapy and bringing new light and better results to the treatment of many cartilage injuries and diseases.This paper reviews the progress of tissue engineering in the treatment of articular cartilage defects.