生物表面活性剂脂肽的发酵生产及抑菌应用研究进展

Recent Progress on Fermentation and Antibacterial Applications of Surfactin

表面活性素(surfactin)是一种环脂肽型生物表面活性剂,具有卓越的表/界面活性,能够显著降低水的表面张力,表现出良好的抗真菌、抗病毒、抗肿瘤、杀虫和抗支原体等生物活性,在医药、农业、食品、日化、石油开采等领域具有很大的应用潜力,但高昂的成本和缺乏竞争力的应用领域使其难以真正地实际应用起来。多年来,大量的研究工作在于促进其工业化应用。综述了surfactin的结构、特性及发酵生产,同时系统的比较和总结了surfactin在抑菌方面的应用研究。

Surfactin is a kind of cyclic lipopeptide biosurfactant mainly synthesized by many Bacillus subtilis strains.Surfactin is well-accepted as one of the most powerful biosurfactants,presents excellent surface activities,can significantly reduce the surface tension force of water to below 27mN/m at a concentration of 10-30mg/L.In addition,surfactin has great biological activities like:anti-fungal,anti-virus,anti-tumor,insecticidal and anti-mycoplasma,and thus has of great applications potential in the fields of medicine,agriculture,food,cosmetics and petroleum industries.However,its real industrial applications were limited by the high production cost and lack of specific application yields.Many efforts have been done towards the improvement of surfactin production.The recent progresses on surfactin production,and its applications as an antibacterial agent have been reviewed.