乌梅丸治疗腹泻型肠易激综合征临床疗效评价

Clinical efficacy of Wumei Wan on diarrhea irritable bowel syndrome

目的:观察乌梅丸结合马来酸曲美布汀片及地衣芽胞杆菌活菌治疗腹泻型肠易激综合征(Diarrhea-type Irritable Bowel Syndrome,IBS-D)的临床疗效。方法:选择2018年3月-2019年1月在湛江中心人民医院及广东燕岭医院内科门诊和住院的IBS-D患者162例。采用随机数字表法将纳入患者分为三组,每组各54例。西医治疗组:采用马来酸曲美布汀联合地衣芽胞杆菌活菌。中医治疗组:采用乌梅丸水煎剂。中西医结合组:采用乌梅丸结合马来酸曲美布汀及地衣芽胞杆菌活菌。比较三组治疗前后各项症状积分变化以及治疗有效率。结果:中西医结合组的治疗有效率明显高于中医治疗组和西医治疗组,差异有统计学意义(P <0.05)。治疗后,三组患者各项症状积分较治疗前明显降低,且中西医结合组患者的各项症状积分明显低于中医治疗组和西医治疗组,差异有统计学意义(P <0.05)。治疗后,三组患者血清神经肽Y(Neuropetide Y,NPY)和P物质(SP)水平较治疗前明显降低,且中西医结合组患者的血清NPY和SP水平明显低于中医治疗组和西医治疗组,差异有统计学意义(P <0.05)。结论:中西医结合方案可以明显改善IBS-D患者临床症状,值得临床推广。

Objective:To observe the clinical efficacy of Wumei Wan(乌梅丸)plus trimebutine maleate and live bacillus licheniformis on diarrhea-type irritable bowel syndrome(IBS-D).Methods:162 IBS-D patients were divided into three groups by random number table method,54 cases in each group.The Western medicine group was given trimebutine maleate plus live bacillus licheniformis.The TCM group was given Wumei Wan.The integrative group was given Wumei Wan plus trimebutine maleate and live bacillus licheniformis.Results:The treatment efficiency in the integrative group was significantly higher than the TCM group and western medicine group,and the difference was statistically significant(P﹤0.05).After treatment,the symptom scores in the three groups were significantly lower than before treatment,and the symptom scores in the integrative group were significantly lower than those in the TCM group and the western medicine group.After treatment,the serum NPY and SP levels in the three groups were significantly lower than before treatment,and the serum NPY and SP levels in the integrated medicine group were significantly lowest than those in the TCM medicine group and the western medicine group.The difference was statistically significant(P﹤0.05).Conclusion:The integrative scheme can obviously improve the clinical symptoms,and it is worthy of clinical promotion.