PD-L1与MTA1在口腔鳞癌中的表达与临床意义

Expression and clinical significance of PD-L1 and MTA1 in the oral squamous cell carcinoma

目的探讨程序性死亡配体1(Programmed death-Ligand1,PD-L1)与转移相关基因1(Metastasis associated gene1,MTA1)在口腔鳞癌组织以及正常口腔粘膜组织中的表达情况、分布状态,二者的相关性及临床意义。方法应用免疫组化方法检测PD-L1与MTA1在45例口腔鳞癌组织及20例正常口腔粘膜组织中的表达情况,分析二者表达的相关性及二者与口腔鳞癌组织临床病理学参数的关系。结果PD-L1在口腔鳞癌组织及正常口腔粘膜组织中的阳性表达率分别为75.56%和15.00%,MTA1在口腔鳞癌组织及正常口腔粘膜组织中的阳性表达率分别为66.67%和10.00%,口腔鳞癌组织及正常粘膜组织的相对表达量具有统计学意义差异(P<0.05)。PD-L1与MTA1的表达与口腔鳞癌的TNM分期有关(P<0.05),口腔鳞癌组织中PD-L1与MTA1的表达有相关性(φ=0.366,P=0.037)。结论PD-L1与MTA1可能在口腔鳞癌发生发展起到重要作用,可能成为潜在的新型联合靶点。

Objective The aims of this study were to investigate the expressions of programmed death-ligand1(PD-L1)and metastasis associated gene 1(MTA1)in oral squamous cell carcinoma and normal oral mucosa tissues as well as their correlation and clinical significance of clinical pathology parameters.Methods The immunohistochemical method was used to detect the expression of PD-L1 and MTA1 in 45 cases of oral squamous cell carcinoma tissues and 20 cases of normal oral mucosa tissues,and to analyze the correlation between their clinical pathological parameters and the expression of PD-L1 and MTA1.Results The positive rates of PD-L1 in oral squamous cell carcinoma and normal oral mucosa tissues were 75.56%and 15%,respectively.The positive rates of MTA1 in oral squamous cell carcinoma and normal oral mucosa tissues were 66.67%and 10%,respectively.The differences were statistically significant(P<0.05).The expression of PD-L1 and MTA1 was related to the TNM stage of oral squamous cell carcinoma(P<0.05),and the expression of PD-L1 and MTA1 in oral squamous cell carcinoma tissues was correlated(r=0.34,P<0.01).Conclusion PD-L1 and MTA1 may play an important role in the development of oral squamous cell carcinoma,and may become a potential new joint target.