溶血磷脂酸在结直肠癌发生发展中的机制研究

The mechanism of lysophosphatidic acid in the development of colorectal cancer

近年来,自分泌运动因子-溶血磷脂酸(Autotaxin-lysophosphatidic acid,ATX-LPA)信号通路在结直肠癌发生发展中的重要性已逐渐得到了医学界的广泛认可。LPA信号可以通过至少6种G蛋白偶联受体(Gprotein-coupled receptors,GPCRs),即LPA1-6,诱导各种细胞进程,包括伤口愈合、分化、增殖、迁移和存活等,这些细胞进程对维持肠上皮屏障的功能、促进结直肠癌细胞的存活、增殖及转移都十分重要。因此,本文对近年来发现的ATX-LPA信号通路与结直肠癌相关炎症的关系,及该信号通路对结直肠癌发生发展过程的影响进行综述,同时也对LPA及相关分子在结直肠癌治疗中的价值前景做出预测。

In recent years,the importance of autotaxin-lysophosphatidic acid(ATX-LPA)signaling pathway in the development of colorectal cancer has gradually been widely recognized by the medical community.LPA signals can induce various cellular processes including wound healing,differentiation,proliferation,migration,and survival through at least 6 G Protein-coupled receptors(GPCRs),that is,LPA1-6.It is very important to maintain the function of intestinal epithelial barrier and promote the survival,proliferation and metastasis of colorectal cancer cells.Therefore,this article reviews the relationship between the ATX-LPA signaling pathway and colorectal cancer-related inflammation discovered in recent years,and the effect of colorectal cancer-related inflammation discovered in recent years,and the effect of this signaling pathway on the development of colorectal cancer.It also reviews LPA and related molecules in colorectal cancer treatment and predicting prospects.