帕金森病流涎症的研究进展

Progress on the Studies about Drooling in Parkinson’s Disease

帕金森病(PD)是一种常见的神经系统退行性疾病。流涎症是PD患者主要的非运动症状之一。目前,PD流涎症尚无统一的诊断标准,也缺乏流涎症治疗的相关证据,肉毒毒素唾液腺内局部注射可能是治疗流涎症最为有效的方式之一。近年来,有关PD流涎症的相关研究有了新进展,文中对PD流涎症的定义、发病机制、流行病学资料、治疗等研究进展做综述。

Parkinson’s disease(PD)is a common neurodegenerative disease.Drooling is one of the main non-motor symptoms of PD.At present,drooling in PD has neither unified diagnostic criteria nor evidence for the treatment.Local injection of botulinum toxin may be one of the most effective ways to treat drooling.In recent years,there has been some new progress in the research of drooling in PD.The definition,pathogenesis,epidemiology,and treatment of drooling in PD were reviewed.