开滦研究年龄≤50岁人群早期血管衰老检出率及影响因素

Early vascular aging and risk factors among a population aged 50 and below in Kailuan study

目的探究开滦研究人群中早期血管衰老检出率及影响因素。方法选取开滦队列中年龄≤50岁、既往无心脑血管病病史且在2010-2016年度完成首次踝臂动脉脉搏波传导速度(baPWV)检测者21952例为观察人群,选取观察人群中无高血压、糖尿病、血脂异常、体质量指数≤25 kg/m^2及不吸烟者1813人为"健康人群",计算不同年龄层中"健康人群"baPWV均值+2倍标准差,作为每个年龄层中早期血管衰老的参考值。计算研究人群中早期血管衰老的检出率。采用逐步后退法多因素Logistic回归模型分析不同年龄层人群和不同性别人群中早期血管衰老的影响因素。结果在总人群中,早期血管衰老检出率为15.0%,其中年龄<30岁人群为12.9%,30~<40岁人群为14.8%,40~50岁人群为15.6%。在总人群中,年龄增加、男性、静息心率升高、高敏C反应蛋白(hsCRP)升高、吸烟、饮酒、高血压、糖尿病是早期血管衰老的影响因素,其OR值(95%CI)分别为1.02(1.01~1.03),2.51(2.10~3.00),1.04(1.03~1.04),1.09(1.05~1.13),1.11(1.04~1.20),1.05(1.00~1.11),3.55(3.13~4.03),1.69(1.38~2.08)。女性人群中,妊娠期高血压患者早期血管衰老的发生风险是正常血压者的4.27倍(95%CI 1.34~13.53)。结论年龄≤50岁人群早期血管衰老检出率为15.0%,其影响因素包括增龄、男性、静息心率升高、hsCRP升高、吸烟、饮酒、高血压、糖尿病;女性人群中,妊娠期高血压是早期血管衰老的影响因素。

Objective To explore the frequency of early vascular aging and risk factors in an adult population with age≤50 years old in Kailuan.Methods A total of 21952 subjects aged≤50 years without previous history of cardiovascular and cerebrovascular diseases and having completed brachial-ankle pulse wave velocity(baPWV)test in 2010-2016 were recruited.The mean+2 standard deviation(mean+2 SD)of baPWV in 1813 healthy population without hypertension,diabetes,dyslipidemia and smoking were calculated and used as the reference value for early vascular aging.The detection rate of early vascular aging in the study population was calculated.The stepwise regression multivariate logistic regression model was used to analyze the influencing factors for early vascular aging in different age and gender groups.Results The average detection rate of early vascular aging in total population was 15.0%with 12.9%in 30 years or less,14.8%between 30 and 40 years,and 15.6%between 40 and 50 years.In the general population,age,male,resting heart rate(HR),high sensitivity C reactive protein(hsCRP),smoking,hypertension,and diabetes were risk factors for early vascular aging with OR values(95%CI)of 1.02(1.01-1.03),2.51(2.10-3.00),1.04(1.03-1.04),1.09(1.05-1.13),1.11(1.04-1.20),1.05(1.00-1.11),3.55(3.13-4.03),1.69(1.38-2.08)respectively.The risk factors for early vascular aging in women with gestational hypertension was 4.27 times higher than those in women without(95%CI 1.34-13.53).Conclusion The frequency of early vascular aging is 15.0%in adult population≤50 years old.Risk factors for early vascular aging include age,male,resting HR,hsCRP,smoking,hypertension,diabetes,and in women,the pregnancy-induced hypertension.