紫杉醇联合顺铂新辅助化疗对宫颈癌的治疗作用分析

Paclitaxel Combined with Cisplatin Neoadjuvant Chemotherapy for Cervical Cancer

目的探讨紫杉醇联合顺铂新辅助化疗对宫颈癌的治疗作用。方法采集我院80例2017年3月至2019年2月宫颈癌患者。随机数字表分组,常规的术后化疗治疗组采取常规术后化疗治疗,术前新辅助化疗方案组则采取紫杉醇联合顺铂新辅助化疗治疗。比较常规的术后化疗治疗组、术前新辅助化疗方案组疗效;手术的平均操作的时间、手术之后住院的总时间;治疗前后患者KPS卡氏健康评分值以及QOL生存质量测评值;手术治疗之后宫颈癌病灶切缘阳性率、淋巴结阳性率。结果术前新辅助化疗方案组疗效、手术的平均操作的时间、手术之后住院的总时间、KPS卡氏健康评分值以及QOL生存质量测评值相比较常规的术后化疗治疗组更好,P<0.05。术前新辅助化疗方案组手术治疗之后宫颈癌病灶切缘阳性率、淋巴结阳性率低于常规的术后化疗治疗组,P<0.05。结论紫杉醇联合顺铂新辅助化疗治疗宫颈癌的效果理想。

Objective To investigate the therapeutic effect of paclitaxel combined with cisplatin neoadjuvant chemotherapy on cervical cancer.Methods 80 cases of cervical cancer in our hospital from March 2017 to February 2019 were collected.Routine post-operative chemotherapy was used in the treatment group,while paclitaxel combined with cisplatin neoadjuvant chemotherapy was used in the pre-operative neoadjuvant chemotherapy group.The curative effect of routine post-operative chemotherapy group and pre-operative neoadjuvant chemotherapy group were compared.The average operation time and the total hospital stay after operation were compared.The KPS score and QOL quality of life of patients before and after treatment were evaluated.The incision margin positive rate and lymph node positive rate of cervical cancer after operation were compared.Result The efficacy,average operation time,total hospitalization time after operation,KPS Karl's health score and QOL quality of life in neoadjuvant chemotherapy group were better than those in conventional chemotherapy group(P<0.05).The positive rate of incision margin and lymph node in neoadjuvant chemotherapy group was lower than that in conventional chemotherapy group(P<0.05).Conclusion Paclitaxel combined with cisplatin neoadjuvant chemotherapy is effective in the treatment of cervical cancer.