甲硝唑三种给药方式治疗滴虫性阴道炎的疗效比较

Comparison of the Efficacy of Metronidazole in the Treatment of Trichomonas Vaginitis

目的研究应用甲硝唑的三种不同给药方式对滴虫性阴道炎进行治疗的效果评价和比较,以方便为临床治疗提供有价值的依据。方法本文研究对象均为我院在2017年1月至2018年10月收治的滴虫性阴道炎患者,共选择93例作为研究对象,将所有患者按照随机方法分为A、B、C 3组,每组患者平均为31例,患者在应用甲硝唑的时候按照不同的给药方案进行干预,A组患者选择甲硝唑多次口服治疗,选择0.2 g甲硝唑用药,每日为患者给药3次;B组患者选择大剂量单次顿服甲硝唑,选择2.0 g甲硝唑口服,每日为患者进行一次给药;C组患者选择采用小剂量甲硝唑口服治疗,选择0.2 g甲硝唑对患者给药,每日为患者用药1次。评价并比较三种不同给药方式,对患者应用的效果。结果对三组患者经过不同治疗以后的临床治疗,总有效率进行比较,A组患者治疗总有效率为83.87%(26/31),B组患者为100.00%(31/31),C组患者为93.55%(29/31),P<0.05,差异存在统计学意义;对三组患者不良反应发生率进行比较,A组为3.23%(1/31),B组为1.61%(5/31),C组为1.29%(4/31),A组不良反应最轻,B组和C组之间无差异。结论对滴虫性阴道炎患者在治疗的过程中,为患者选择采用甲硝唑大剂量单次顿服的用药方式能够更好的提升治疗效果,而且治疗的安全性也比较理想,值得推广使用。

Objective To evaluate and compare the efficacy of three different administration methods of metronidazole in the treatment of trichomonas vaginitis,so as to provide valuable basis for clinical treatment.Method In this paper,the research object of our hospital in January 2017 to October 2018,trichomonas vaginitis treated patients,93 cases with choice as the research object,all patients according to random method can be divided into A,B and C 3 group,each group of patients with an average of 31 cases,so the patient at the time of application of metronidazole in accordance with the different dosage regimen to intervene,A group of patients choose metronidazole oral therapy for many times,choose 0.2 g metronidazole,for patients to the medicine three times A day,at the same time in the patient's vagina placed 0.2 g of metronidazole effervescent tablets,application for patients on A daily,continuous treatment of A week;In group B,large dose of metronidazole was taken in a single dose,and 2.0g of metronidazole was taken orally,and the drug was given to patients once a day.Patients in group C were treated with small-dose metronidazole orally,and 1.6g metronidazole was administered to patients twice a day.At the same time,0.2 g metronidazole effervescent tablets were placed into the vagina of the patient for drug administration,once a day for the patient,and continuous treatment for 7 days.To evaluate and compare the effects of three different administration methods on patients.Results The total effective rate of the patients in the three groups after different treatments was compared.The total effective rate of the patients in the group A was 83.87%(26/31),the patients in the group B was 100.00%(31/31),and the patients in the group C was 93.55%(29/31),P<0.05,the difference was statistically significant.The incidence of adverse reactions was compared among the three groups:group A was 3.23%(1/31),group B was 1.61%(5/31),and group C was 1.29%(4/31).Adverse reactions were the least severe in group A,and there was no difference between group B and C.Conclusion In the treatment of trichomonas vaginitis patients,the single dose of metronidazole for patients can better improve the treatment effect,and the safety of treatment is also ideal,worthy of promotion.