左乙拉西坦单药在小儿癫痫治疗中的安全性及可行性

The Safety and Feasibility of Levoethiracetam in the Treatment of Pediatric Epilepsy

目的研究分析左乙拉西坦单药在小儿癫痫治疗中的效果与安全性。方法选我院2017年8月至2018年8月接收的癫痫患儿100例为研究对象。采用随机数表法分为对照组与观察组,两组患儿均50例。对照组患儿应用常规方法治疗,观察组患儿采用左乙拉西坦单药治疗。对照两组患儿临床治疗情况。结果观察组患儿治疗有效率为96.0%,对照组为80.0%,检验数据P<0.05,符合统计学意义,且观察组患儿家属治疗满意度要高于对照组,数据具有统计学意义(P<0.05);治疗前两组患儿操作智商评分、语言智商评分以及总智商评分无明显区别,治疗后均改善,观察组患儿改善效果优于对照组,检验数据P<0.05,符合统计学意义;对比两组患儿不良反应发生率,观察组与对照组并无明显区别,经检验数据P>0.05,不符合统计学意义。结论治疗小儿癫痫,相比较常规治疗措施,左乙拉西坦单药治疗效果更显著,更能够改善患儿临床症状,且减少不良反应发生,临床应用效果较好。

Objective To study and analyze the efficacy and safety of levoethiracetam monotherapy in the treatment of pediatric epilepsy.Methods 100 cases of epileptic children admitted to our hospital from August 2017 to August 2018 were selected as subjects.The patients were divided into control group and observation group by random number table method.The children in the control group were treated with conventional methods,while the children in the observation group were treated with lethiracetam monotherapy.The clinical treatment of the two groups was compared.Results The effective rate was 96.0%in the observation group and 80.0%in the control group.The test data P<0.05 was statistically significant,and the treatment satisfaction of the family members of the observation group was higher than that of the control group(P<0.05).Before treatment,there was no significant difference in the scores of children's operational IQ,language IQ and total IQ between the two groups,which were improved after treatment.The improvement effect of children in the observation group was better than that in the control group,and the test data P<0.05 was statistically significant.The incidence of adverse reactions in the two groups was compared,and there was no significant difference between the observation group and the control group.The tested data was P>0.05,which was not statistically significant.Conclusion Compared with the conventional treatment for pediatric epilepsy,the treatment effect of levoethiracetam monotherapy is more significant,which can improve the clinical symptoms of children and reduce the occurrence of adverse reactions.The clinical application effect is better.