低分子肝素与华法林抗凝治疗肺栓塞的临床疗效比照观察

Comparison Observation of the Clinical Efficacy of Low Molecular Weight Heparin and Warfarin in theTreatment of Pulmonary Embolism

目的探讨低分子肝素与华法林抗凝治疗肺栓塞的临床疗效比照。方法纳入我院100例2017年2月至2018年11月肺栓塞患者。随机数字表分组,华法林抗凝治疗组对于肺栓塞的患者选择华法林抗凝治疗,低分子肝素抗凝治疗组则对于肺栓塞的患者选择低分子肝素抗凝治疗。比对两组疗效;咳嗽症状消失时间、胸痛消失时间、呼吸困难消失时间、临床血气指标恢复正常的时间;治疗前后患者凝血的相关监测指标以及动脉血气监测指标;血小板减少、出血发生率。结果低分子肝素抗凝治疗组疗效、咳嗽症状消失时间、胸痛消失时间、呼吸困难消失时间、临床血气指标恢复正常的时间、凝血的相关监测指标以及动脉血气监测指标相比华法林抗凝治疗组有优势,P<0.05。低分子肝素抗凝治疗组血小板减少、出血发生率低于华法林抗凝治疗组,P<0.05。结论低分子肝素抗凝治疗肺栓塞的疗效肯定,可有效改善患者的凝血功能,改善血气分析指标,加速患者临床症状消退,缩短治疗的时间,且安全性更高。

Objective To compare the clinical efficacy of low molecular weight heparin and warfarin in the treatment of pulmonary embolism.Methods 100 patients with pulmonary embolism in our hospital from February 2017 to November 2018 were enrolled.Randomized number table grouping,warfarin anticoagulation treatment group for patients with pulmonary embolism warfarin anticoagulation treatment,low molecular weight heparin anticoagulation treatment group for patients with pulmonary embolism choose low molecular weight heparin anticoagulation treatment.The curative effect was compared between the two groups;cough symptom disappearance time,chest pain disappearance time,dyspnea disappearance time,clinical blood gas index return to normal time;coagulation related monitoring indicators and arterial blood gas monitoring indicators before and after treatment;thrombocytopenia,bleeding rate.Result Compared with warfarin anticoagulant therapy group,low molecular weight heparin anticoagulant therapy group had advantages in curative effect,cough symptom disappearance time,chest pain disappearance time,dyspnea disappearance time,clinical blood gas index recovery time,coagulation related monitoring index and arterial blood gas monitoring index,P<0.05.The incidence of thrombocytopenia and hemorrhage in low molecular weight heparin anticoagulation group was lower than that in warfarin anticoagulation group(P<0.05).Conclusion Low molecular weight heparin anticoagulation therapy is effective in treating pulmonary embolism.It can effectively improve the coagulation function of patients,improve blood gas analysis index,accelerate the clinical symptoms of patients,shorten the treatment time,and has higher safety.