老年胃食管反流病行雷贝拉唑联合莫沙必利治疗的疗效观察

Observation on the Curative Effect of Rabeprazole Combined with Moxapride in Elderly Patients with Gastroesophageal Reflux Disease

目的观察并分析联合应用雷贝拉唑与莫沙必利对老年胃食管反流病(GERD)患者进行治疗的临床效果。方法选取92例来我院接受治疗的老年GERD患者为研究对象,按入院先后顺序将其分成两组,单纯口服雷贝拉唑的为对照组,在此基础上加用莫沙必利进行治疗的则为观察组。对比两组患者的药物治疗效果,并进行评价。结果①Demeester评分方面,两组患者治疗前的评分差异不大,无统计学意义(P>0.05);但观察组患者治疗后的评分要显著低于对照组,数据差异明显,P<0.05,有统计学意义。②治疗总有效率方面,观察组患者的治疗总有效率达到了95.7%,相比于对照组的80.4%明显升高(P<0.05)。③不良反应发生率方面,观察组与对照组(10.9%VS 8.7%)差异不大,无统计学意义(P>0.05)。结论对于老年GERD患者,通过联合应用雷贝拉唑与莫沙必利对其进行治疗,可有效缓解患者病理性反酸症状,且疗效显著,安全可靠,值得重视。

Objective To observe and analyze the clinical effect of combined use of rabeprazole and moxapride in the treatment of GERD.Methods 92 elderly GERD patients who received treatment in our hospital were selected as the study subjects,and divided into two groups according to the order of admission.The control group was treated with rabeprazole alone,and the observation group was treated with moxapride.The efficacy of drug therapy was compared and evaluated between the two groups.Results(1)Demeester scoring,there was no significant difference between the two groups before treatment(P>0.05).However,the scores of patients in the observation group after treatment were significantly lower than those in the control group,with significant difference in data(P<0.05),statistically significant.(2)In terms of total effective rate,the total effective rate of treatment in the observation group reached 95.7%,which was significantly higher than 80.4%in the control group(P<0.05).(3)In terms of the incidence of adverse reactions,there was no significant difference between the observation group and the control group(10.9%VS8.7%)(P>0.05).Conclusion For elderly GERD patients,the combined treatment of rabeprazole and moxapride can effectively relieve the symptoms of pathological acid reflux in patients with significant efficacy,safety and reliability,which is worthy of attention.