尼可地尔治疗冠状动脉慢血流的临床效果

Clinical effect of Nicorandil in the treatment of coronary slow flow

目的探讨尼可地尔治疗冠状动脉慢血流(CSF)的临床效果,为更有效地治疗CSF患者提供参考。方法选取2016年12月~2018年6月于武汉市第三医院行冠状动脉造影(GAG)且诊断为CSF的126例患者作为研究对象,根据随机数字表法将其分为对照组(64例)和联合治疗组(62例)。对照组患者给予常规治疗,而联合治疗组患者在此基础上给予尼可地尔治疗。患者每月随访1次,随访6个月。观察两组患者治疗前后的症状、血常规、炎症因子、同型半胱氨酸、血小板聚集率的变化情况,并比较两组患者治疗后的不良反应发生情况。结果治疗后,两组患者的总胆固醇、三酰甘油、超敏C反应蛋白、白介素-1、白介素-6、内皮素-1、同型半胱氨酸、血小板聚集率均低于本组治疗前,一氧化氮均高于本组治疗前,差异有统计学意义(P<0.05);联合治疗组患者治疗后的总胆固醇、三酰甘油、超敏C反应蛋白、白介素-1、白介素-6、内皮素-1、同型半胱氨酸、血小板聚集率均低于对照组,一氧化氮高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者的胸痛、心律失常和胸闷发生率均低于本组治疗前,差异有统计学意义(P<0.05);联合治疗组患者治疗后的胸痛、胸闷发生率均低于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论在常规治疗的基础上联合使用尼可地尔,可更显著改善患者的CSF症状和炎症反应。

Objective To investigate the clinical effect of Nicorandil in the treatment of coronary slow flow(CSF),thus providing reference for more effective treatment in CSF patients.Methods A total of 126 patients who underwent coronary angiography(GAG)and diagnosed with CSF in Wuhan Third Hospital from December 2016 to June 2018 were selected as the research objects,and they were divided into control groups(64 cases)and combined treatment group(62 cases)according to the random number table method.Patients in the control group were given conventional treatment,while patients in the combined treatment group were given Nicorandil treatment on the basis of conventional treatment.Patients were followed up once a month for 6 months.The changes of symptoms,blood routine,inflammatory factors,homocysteine,and platelet aggregation rate of the two groups of patients before and after treatment were observed,and the incidence of adverse reactions between the two groups of patients after treatment was compared.Results After treatment,the total cholesterol,triacylglycerol,high-sensitivity C-reactive protein,interleukin-1,interleukin-6,endothelin-1,homocysteine,and platelet aggregation rate in both groups were lower than those before treatment,nitric oxide was higher than that before treatment,and the differences were statistically significant(P<0.05).The total cholesterol,triacylglycerol,high-sensitivity C-reactive protein,interleukin-1,interleukin-6,endothelin-1,homocysteine,and platelet aggregation rate after treatment in the combined treatment group were lower than those in the control group,nitric oxide was higher than that in the control group,and the differences were statistically significant(P<0.05).After treatment,the incidence rates of chest pain,arrhythmia and chest tightness of the two groups of patients were lower than those before treatment,and the differences were statistically significant(P<0.05).The incidence rates of chest pain and chest tightness in the combined treatment group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence rate of adverse reactions between the two groups(P>0.05).Conclusion The combination of Nicorandil and conventional treatment can improve symptoms and inflammatory status in CSF patients more significantly.