2型糖尿病肾病与血糖波动及氧化应激水平的相关性分析

Correlation analysis of type 2 diabetic nephropathy with blood glucose fluctuation and oxidative stress

目的探讨2型糖尿病肾病与血糖波动及氧化应激水平的相关性。方法选取2015年1月~2017年12月在我院就诊的90例2型糖尿病患者作为研究对象,根据24 h尿微量清蛋白(UAlb)测定结果,分为正常UAlb组(43例)和高UAlb组(47例)。记录两组患者的一般临床资料以及血糖、血脂等生化指标,并检测氧化应激指标超氧化物歧化酶(SOD)、丙二醛(MDA)水平,完善7段自我血糖监测,计算血糖水平标准差(SDBG)。结果两组患者的空腹血糖(FBG)、糖化血红蛋白(HbA1c)、收缩压、舒张压、病程、SDBG、SOD、MDA、UAlb比较,差异均有统计学意义(P<0.05);相关分析结果显示,2型糖尿病患者的UAlb与病程、SDBG、MDA成正相关(r=0.298、0.435、0.673,P<0.05);UAlb与SOD成负相关(r=-0.716,P<0.05);SOD与SDBG成负相关(r=-0.294,P<0.05);MDA与SDBG成正相关(r=0.282,P<0.05)。结论糖尿病病程、血糖波动、氧化应激水平与糖尿病肾病的发生发展具有相关性。

Objective To explore the correlation between type 2 diabetic nephropathy and blood glucose fluctuation and oxidative stress.Methods A total of 90 patients with type 2 diabetes who were admitted to our hospital from January 2015 to December 2017 were selected.According to the 24-hour urine microalbumin(UAlb)determination results,they were divided into the normal UAlb group(43 cases)and the high UAlb group(47 cases).General clinical data,blood glucose,blood lipid and other biochemical indicators of patients in the 2 groups were recorded,and the levels of oxidative stress index superoxide dismutase(SOD)and malondialdehyde(MDA)were detected.The seven-stage self-monitoring of blood glucose was improved,and the standard deviation of blood glucose level(SDBG)was calculated.Results Fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),systolic blood pressure,diastolic blood pressure,course of diabetes,SDBG,SOD,MDA,and UAlb of the two groups were compared,and the differences were statistically significant(P<0.05).The results of correlation analysis showed that UAlb was positively correlated with the course of disease,SDBG and MDA in patients with type 2 diabetes(r=0.298,0.435,0.673,P<0.05).There was a negative correlation between UAlb and SOD(r=-0.716,P<0.05).SOD was negatively correlated with SDBG(r=-0.294,P<0.05).MDA was positively correlated with SDBG(r=0.282,P<0.05).Conclusion The course of diabetes,the fluctuation of blood glucose and the level of oxidative stress are correlated with the occurrence and development of diabetic nephropathy.