复方五味子口服液的制备及抗疲劳功能评价

Preparation and anti fatigue evaluation of compound Schisandra oral liquid

目的研究复方五味子口服液的制备工艺,并对其抗疲劳功能进行评价。方法选用五味子、黄芪、覆盆子为原料,制成复方五味子口服液;通过不同料液比、提取温度、提取次数、提取时间进行单因素正交实验以确定最优提取方法;选取ICR雄性小鼠,观察复方五味子口服液低、中、高剂量组的抗疲劳作用。结果复方五味子口服液的最佳提取工艺为:料液比1∶40,提取时间3 h,提取温度90℃,提取次数3次;复方五味子口服液可增加小鼠的运动耐力,提高小鼠的负重游泳时间和体内肝糖原的水平,降低血清尿素氮和血乳酸等指标的水平。结论复方五味子口服液制备工艺稳定、可行,具有明显的抗疲劳作用。

Objective To study the preparation technology of compound Schisandra oral liquid and evaluate its anti fatigue function.Methods The compound Schisandra oral liquid was made with Schisandra,Astragalus and Raspberry as raw materials.The optimal extraction method was determined by single factor orthogonal experiment with different material liquid ratio,extraction temperature,extraction times and extraction time.The anti fatigue effect of low,medium and high dose group of compound Schisandra oral liquid was observed in ICR male mice.Results The best extraction technology of compound Schisandra oral liquid isthe ratio of material to liquid is 1∶40,the extraction time is 3 hours,the extraction temperature is 90℃,the extraction times are 3 times.Compound Schisandra oral liquid can increase the exercise endurance of mice,improve the load-bearing swimming time and the level of liver glycogen in mice,and reduce the level of serum urea nitrogen and blood lactate.Conclusion The preparation technology of compound Schisandra oral liquid is stable and feasible,and has obvious anti fatigue effect.